MP36-04 LOW TESTOSTERONE IS COMMON IN PATIENTS WITH ANTERIOR URETHRAL STRICTURE: RISK-FACTOR OR COINCIDENCE?

Abstract

You have accessJournal of UrologyTrauma/Reconstruction/Diversion: Urethral Reconstruction (including Stricture, Diverticulum) I1 Apr 2017MP36-04 LOW TESTOSTERONE IS COMMON IN PATIENTS WITH ANTERIOR URETHRAL STRICTURE: RISK-FACTOR OR COINCIDENCE? Jeffrey Spencer, Michael Daughtery, Stephen Blakely, Dmitriy Nikolavsky, and Timothy Byler Jeffrey SpencerJeffrey Spencer More articles by this author , Michael DaughteryMichael Daughtery More articles by this author , Stephen BlakelyStephen Blakely More articles by this author , Dmitriy NikolavskyDmitriy Nikolavsky More articles by this author , and Timothy BylerTimothy Byler More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2017.02.1115AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Testosterone is known to have key involvement in urethral development with devastating consequences in its absence. It has also been shown to have an important role in mucosal healing. We hypothesized that urethral stricture formation may form in the background of low testosterone. We aimed to evaluate a hypothesis by McCullough and colleagues regarding an increased prevalence of low testosterone found in men with anterior urethral strictures. METHODS Using a prospectively maintained male urethral stricture database from February 2014 to September 2016, we identified all men treated for anterior urethral stricture with a serum total testosterone level and stratified them by age. Prior to reconstruction, men with anterior urethral strictures had been advised to have testosterone levels drawn. Patients with radiation-induced stricture or pelvic fracture urethral distraction injuries were excluded. Prevalence of low-testosterone, defined as serum testosterone less than 300ng/dL, was calculated. Age-matched data from a national database (NHANES), were used as a reference. RESULTS We identified 68/103 (66%) men with anterior urethral strictures who had pre-operative testosterone levels measured. Of these, an additional 5 were excluded for a study group of 63 patients. Figure 1 describes the prevalence of low testosterone in our cohort and the NHANES database stratified by age group. Overall, low testosterone was found in 47.6% of men in the anterior urethral strictures group and 27.5% of patients in the national database. CONCLUSIONS Low testosterone is more common in this group of patients with urethral strictures than can be expected in the general population based on a national database. Further investigation is warranted into the relationship between serum testosterone and idiopathic anterior stricture formation. © 2017FiguresReferencesRelatedDetails Volume 197Issue 4SApril 2017Page: e467 Advertisement Copyright & Permissions© 2017MetricsAuthor Information Jeffrey Spencer More articles by this author Michael Daughtery More articles by this author Stephen Blakely More articles by this author Dmitriy Nikolavsky More articles by this author Timothy Byler More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...