MP35-17 “PEE”BUST TRIAL-A SINGLE CENTRE PROSPECTIVE RANDOMISED STUDY COMPARING FUNCTIONAL AND ANATOMIC OUTCOMES AFTER SUBSTITUTION URETHROPLASTY WITH “BUCCAL MUCOSA GRAFT VERSUS INNER PREPUTIAL SKIN GRAFT” FOR ANTERIOR URETHRAL STRICTURE DISEASE

Abstract

You have accessJournal of UrologyTrauma/Reconstruction/Diversion: Urethral Reconstruction (including Stricture, Diverticulum) I (MP35)1 Apr 2020MP35-17 “PEE”BUST TRIAL-A SINGLE CENTRE PROSPECTIVE RANDOMISED STUDY COMPARING FUNCTIONAL AND ANATOMIC OUTCOMES AFTER SUBSTITUTION URETHROPLASTY WITH “BUCCAL MUCOSA GRAFT VERSUS INNER PREPUTIAL SKIN GRAFT” FOR ANTERIOR URETHRAL STRICTURE DISEASE Shantanu Tyagi*, Arup Kumar Mandal, Shrawan Kumar Singh, Ravi Mavuduru, Girdhar Bora, Kalpesh Parmar, Sudheer Devana, and Aditya Sharma Shantanu Tyagi*Shantanu Tyagi* More articles by this author , Arup Kumar MandalArup Kumar Mandal More articles by this author , Shrawan Kumar SinghShrawan Kumar Singh More articles by this author , Ravi MavuduruRavi Mavuduru More articles by this author , Girdhar BoraGirdhar Bora More articles by this author , Kalpesh ParmarKalpesh Parmar More articles by this author , Sudheer DevanaSudheer Devana More articles by this author , and Aditya SharmaAditya Sharma More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000000879.017AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: The optimal choice of graft for Substitution Urethroplasty (SU) remains debated at present. This can be attributed to the paucity of well-conducted prospective randomized trials on comparative outcomes after the usage of various graft materials for SU. The objective of our study was to prospectively assess the results of SU performed with either Inner Preputial Graft (IPG) or Buccal Mucosa Graft (BMG) so as to identify the “best substitution material” based on Functional and Anatomic success. METHODS: From January 2018 to September 2019, 100 patients with anterior urethral stricture disease, complying with strict inclusion and exclusion criteria, were prospectively randomized to undergo SU with either IPG or BMG (Fig.1,2). Anatomic Variables (Uroflowmetry, Retrograde and Voiding cystourethrography) and Functional variables (LUTS, Sexual function) were assessed pre-operatively and post-operatively at predefined intervals. Success was defined by “Both” Functional outcomes and Anatomic outcomes. RESULTS: Mean follow-up was 15 months (3–19). The overall success rate was 83% (84% in the BMG and 81% in the IPG arm). At 18 months, Mean Qmax was comparable between two arms (22ml/s in BMG and 19ml/s in IPG arm), Mean IPSS (2.4 v/s 2.6) and Mean IIEF (21.60 v/s 21) were also comparable between BMG v/s IPG arm respectively. Intraoperative blood loss (35 v/s 53ml) and Hospital stay (3.37 v/s 4.50 days) were significantly less in IPG arm. Orgasmic Domain of IIEF was surprisingly better in IPG arm at 6 months. CONCLUSIONS: Our study is among the first such attempt to determine the non-inferior and comparable success rates after SU with IPG v/s BMG through a prospective randomized methodology. Source of Funding: none © 2020 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 203Issue Supplement 4April 2020Page: e519-e519 Advertisement Copyright & Permissions© 2020 by American Urological Association Education and Research, Inc.MetricsAuthor Information Shantanu Tyagi* More articles by this author Arup Kumar Mandal More articles by this author Shrawan Kumar Singh More articles by this author Ravi Mavuduru More articles by this author Girdhar Bora More articles by this author Kalpesh Parmar More articles by this author Sudheer Devana More articles by this author Aditya Sharma More articles by this author Expand All Advertisement PDF downloadLoading ...