MP35-16 PILOT STUDY EVALUATING 99MTC-SESTAMIBI SPECT/CT FOR THE DIFFERENTIATION OF ONCOCYTOMA FROM RENAL CELL CARCINOMA

Abstract

You have accessJournal of UrologyKidney Cancer: Evaluation and Staging I1 Apr 2015MP35-16 PILOT STUDY EVALUATING 99MTC-SESTAMIBI SPECT/CT FOR THE DIFFERENTIATION OF ONCOCYTOMA FROM RENAL CELL CARCINOMA Michael Gorin, Steven Rowe, Jennifer Gordetsky, Mark Ball, Phillip Pierorazio, Jonathan Epstein, Mehrbod Javadi, and Mohamad Allaf Michael GorinMichael Gorin More articles by this author , Steven RoweSteven Rowe More articles by this author , Jennifer GordetskyJennifer Gordetsky More articles by this author , Mark BallMark Ball More articles by this author , Phillip PierorazioPhillip Pierorazio More articles by this author , Jonathan EpsteinJonathan Epstein More articles by this author , Mehrbod JavadiMehrbod Javadi More articles by this author , and Mohamad AllafMohamad Allaf More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2015.02.1117AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Currently available cross-sectional imaging techniques are unable to reliably distinguish oncocytoma from renal cell carcinoma (RCC). As a result, a large number of patients harboring an oncocytoma undergo unnecessary surgical resection. Compared to RCC, oncocytomas are unique in that at the ultra-structural level these tumors are comprised of cells with numerous densely packed mitochondria. In this study we tested the hypothesis that oncocytomas can be differentiated from RCC on the basis of increased uptake of the mitochondrial imaging agent 99mTc-sestamibi. METHODS In total, 6 patients (3 with oncocytoma and 3 with RCC [1 clear cell, 1 Xp11.2 translocation and 1 unclassified type]) were imaged with 99mTc-sestamibi SPECT/CT. Relative quantification was performed by measuring tumor to normal renal parenchyma background ratios. RESULTS All 3 oncocytomas demonstrated radiotracer uptake near or above that of the normal renal parenchyma (uptake ratios: 0.85, 1.10 & 1.78; Figure 1). In contrast, the three RCCs were profoundly photopenic relative to renal background (uptake ratios: 0.21, 0.26 & 0.31; Figure 2). CONCLUSIONS 99mTc-sestamibi SPECT/CT appears to be of value in distinguishing oncocytoma from RCC. To more rigorously assess the diagnostic accuracy of this imaging modality, we have initiated a trial (ClinicalTrials.gov identifier NCT02160925) to prospectively study patients with clinical T1 renal tumors scheduled to undergo surgical resection. © 2015 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 193Issue 4SApril 2015Page: e425-e426 Advertisement Copyright & Permissions© 2015 by American Urological Association Education and Research, Inc.MetricsAuthor Information Michael Gorin More articles by this author Steven Rowe More articles by this author Jennifer Gordetsky More articles by this author Mark Ball More articles by this author Phillip Pierorazio More articles by this author Jonathan Epstein More articles by this author Mehrbod Javadi More articles by this author Mohamad Allaf More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...