MP34-19 PERIOPERATIVE AND LONG-TERM INFECTIOUS COMPLICATIONS AFTER RADICAL CYSTECTOMY: A PROSPECTIVE OBSERVATIONAL STUDY

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You have accessJournal of UrologyCME1 Apr 2023MP34-19 PERIOPERATIVE AND LONG-TERM INFECTIOUS COMPLICATIONS AFTER RADICAL CYSTECTOMY: A PROSPECTIVE OBSERVATIONAL STUDY Benedikt Ebner, Judith Hirsch, Yannic Volz, Lennert Eismann, Benazir Abrarova, Robert Bischoff, Nikolaos Pyrgidis, Julian Hermans, Christian Stief, and Gerald Bastian Schulz Benedikt EbnerBenedikt Ebner More articles by this author , Judith HirschJudith Hirsch More articles by this author , Yannic VolzYannic Volz More articles by this author , Lennert EismannLennert Eismann More articles by this author , Benazir AbrarovaBenazir Abrarova More articles by this author , Robert BischoffRobert Bischoff More articles by this author , Nikolaos PyrgidisNikolaos Pyrgidis More articles by this author , Julian HermansJulian Hermans More articles by this author , Christian StiefChristian Stief More articles by this author , and Gerald Bastian SchulzGerald Bastian Schulz More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000003268.19AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Radical cystectomy (RC) is associated with a high risk of infectious complications. This risk does not only apply for the perioperative phase, but also for the long-term. Despite significant morbidity, these complications are inadequately investigated. This is the first prospective study that systematically assesses infectious complications after RC. METHODS: Patients undergoing RC because of oncological and non-oncological indications are prospectively enrolled in this ongoing observational study. Perioperative parameters are assessed at standardized time points and include infectious laboratory parameters (leukocytes, CRP, IL-6, Procalcitonin) as well as microbiological analyses (wound drainage, urine samples). Follow-up examinations are performed 3, 6, and 12 months after surgery and include questionnaires, blood tests, and urosonography. An Ethical Committee approval has been obtained and the study has been registered on ClinicalTrials.gov (NCT05153694). RESULTS: We performed an interim analysis of 50 patients. The median age was 69 years (84% male, 16% female). 40.0% received an ileal conduit (IC) and 60.0% a neobladder (NB). 50.0% of patients presented with a urinary tract infection preoperatively, but only 25.0% reported dysuria. The hospital antibiotic (AB) prophylaxis standard of cefuroxime (5 d) and metronidazole (3 d) was extended in 97.6% of patients. Microbiological analysis of the wound drainage on the 1st postoperative day (POD) showed bacterial growth in 18.2%. The urine culture on the 8th POD was positive in 65.9%. 40.0% had at least one episode of fever (≥38°C) during the inpatient stay. The incidence of fever between IC and NB was not significantly different (OR 0.88; p=0.24). Also, there was no significant association between the level of IL-6 on the 1 st POD or the results of the microbiological analyses (wound drainage and urine samples) and the occurrence of fever (p=0.82; p=0.83; p=0.93, respectively). 50.0% reported the intake of at least one AB drug and 31.4% reported an emergency consultation due to RC-associated fever in the first 3 months after surgery, respectively. There was no significant difference between IC and NB for these follow-up results (p=0.17; p=0.55, respectively). CONCLUSIONS: This is the first systematic and comprehensive prospective study assessing infectious complications after RC. Importantly, our preliminary results indicate that these complications are severely underestimated both during the inpatient stay, but also in the long-term. Source of Funding: None © 2023 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 209Issue Supplement 4April 2023Page: e467 Advertisement Copyright & Permissions© 2023 by American Urological Association Education and Research, Inc.MetricsAuthor Information Benedikt Ebner More articles by this author Judith Hirsch More articles by this author Yannic Volz More articles by this author Lennert Eismann More articles by this author Benazir Abrarova More articles by this author Robert Bischoff More articles by this author Nikolaos Pyrgidis More articles by this author Julian Hermans More articles by this author Christian Stief More articles by this author Gerald Bastian Schulz More articles by this author Expand All Advertisement PDF downloadLoading ...