Abstract
observed in chemo-resistant patients (**p< 0.01), which also showed correlation to prognosis. Similar results obtain by qPCR array. Furthermore, Oct4 and Nanog expression were also upregulated in multidrug resistant (253J-ADM) cell compared with parental cell, the higher tumorigenesis ability were also observed by in vitro and in vivo tumorigenesis assay(*p<0.05). Knocking down of Oct4 or Nanog in multidrug resistant BCa cell line dramatically suppressed cell renew ability (*p<0.05) and enhanced chemosensitivity to chemo-drugs (mitomycin/ pirarubicin) (*p<0.05). CONCLUSIONS: These data indicate that cancer stem-like properties were expanded during the acquisition of multidrug resistance in BCa. Clinically, BCa stemness markers (Oct4 and nanog) overexpression may promote the BCa recurrence to resist multidrugs, which could be a potential therapeutic target for chemoresistant BCa treatment.
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