MP34-10 MALE AGE IN IN VITRO FERTILIZATION RESULTS: DOES IT MATTER?

Abstract

You have accessJournal of UrologyCME1 May 2022MP34-10 MALE AGE IN IN VITRO FERTILIZATION RESULTS: DOES IT MATTER? Mariangela Badalotti, Isadora Badalotti-Teloken, Victória Campos Dornelles, Marta Ribeiro Hentschke, Fernando Badalotti, Natalia Vasconcelos, Alvaro Petracco, and Claudio Teloken Mariangela BadalottiMariangela Badalotti More articles by this author , Isadora Badalotti-TelokenIsadora Badalotti-Teloken More articles by this author , Victória Campos DornellesVictória Campos Dornelles More articles by this author , Marta Ribeiro HentschkeMarta Ribeiro Hentschke More articles by this author , Fernando BadalottiFernando Badalotti More articles by this author , Natalia VasconcelosNatalia Vasconcelos More articles by this author , Alvaro PetraccoAlvaro Petracco More articles by this author , and Claudio TelokenClaudio Teloken More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000002588.10AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: The advanced female age is well documented as a risk factor for pregnancy outcomes, whereas the impact of male age is still not well established in the literature. With the tendency to delay childbearing, understanding the actual effect of paternal age in fecundity becomes crucial. Some studies suggest that 40 years could be the milestone for declining male reproductive life, as is 35 years for women’s reproductive life. Thus, the objective of this study was to evaluate the impact of male age on gestational outcomes in In Vitro fertilization (IVF). METHODS: Retrospective, observational study that included a total of 4603 IVF cycles, between 2010 and 2020. Gestational outcomes in fresh embryo transfers (embryos from fresh oocytes inseminated with ejaculated sperm) were analyzed according to male age. Couples with men up to 69 yo and women up to 45 yo were included. Transfer cycles with embryo biopsy and donated gametes cycles were excluded. The men were divided into groups (<40 yo and ≥40 yo) and compared. Secondly, in each group, the women were also divided into two groups (<35 yo and ≥35 yo), and the couple’s outcomes were compared. The variables analyzed were positive hCG, clinical and biochemical pregnancy, abortion and birth rates. The statistical analysis was performed using the Chi-square test, considering p <0.05 statistically significant. RESULTS: A total of 4603 IVF cycles carried out between 2010 and 2020 were analyzed. The results according to male's age <40 yo and ≥40 yo are shown in Table 1. The results considering the female age are shown in Table 2. CONCLUSIONS: In this study, male age matters for IVF results. There were significantly more clinical pregnancy and live birth rates in males aged <40 years old. When considering maternal age, the male age seems to impact IVF results in women with <35 yo and ≥35 yo. Also, age less than 40 was presented as a protector factor for miscarriage. Source of Funding: The authors had their own source of funding © 2022 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 207Issue Supplement 5May 2022Page: e582 Advertisement Copyright & Permissions© 2022 by American Urological Association Education and Research, Inc.MetricsAuthor Information Mariangela Badalotti More articles by this author Isadora Badalotti-Teloken More articles by this author Victória Campos Dornelles More articles by this author Marta Ribeiro Hentschke More articles by this author Fernando Badalotti More articles by this author Natalia Vasconcelos More articles by this author Alvaro Petracco More articles by this author Claudio Teloken More articles by this author Expand All Advertisement PDF DownloadLoading ...