MP33-10 QUANTITATIVE INVESTIGATION OF ZINC, SELENIUM, STRONTIUM AND LEAD IN HUMAN URINARY CALCULI BY USING INDUCTIVELY COUPLED PLASMA OPTICAL EMISSION SPECTROMETRY

Abstract

You have accessJournal of UrologyStone Disease: Basic Research I1 Apr 2015MP33-10 QUANTITATIVE INVESTIGATION OF ZINC, SELENIUM, STRONTIUM AND LEAD IN HUMAN URINARY CALCULI BY USING INDUCTIVELY COUPLED PLASMA OPTICAL EMISSION SPECTROMETRY Mahmoud El-Naggar, Bedeir Ali-El-Dein, Sanjeev Mehta, Naimat Alsaigh, and Manoj Monga Mahmoud El-NaggarMahmoud El-Naggar More articles by this author , Bedeir Ali-El-DeinBedeir Ali-El-Dein More articles by this author , Sanjeev MehtaSanjeev Mehta More articles by this author , Naimat AlsaighNaimat Alsaigh More articles by this author , and Manoj MongaManoj Monga More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2015.02.571AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Many heavy metals and trace elements are incorporated in urinary stones and could play a role in urolithiasis. The aim of this study was to quantatively evaluate the levels of Zinc (Zn), Selenium (Se), Strontium and Lead (Pb) in urinary stones from different geographical regions. METHODS 1173 urinary stones were collected from 10 different International Hospitals. The stones were cleaned, washed and dried, then subjected to multi-elemental microanalysis by Inductively Coupled Plasma Optical Emission Spectrometry (ICP-OES) to determine the concentrations of 4 heavy elements (Zn, Se, Sr and Pb) in addition to Calcium (Ca). Data were analyzed using SPSS software RESULTS There were 791 stones from males (67.4%) and 382 (32.6%) from females. The mean age was 45.25±13.3 years. The mineralogical types of stones were; Ca oxalate (51.7%), Ca phosphate (26.6%) and uric acid stones (21.7%). The mean Ca concentration was 157611± 209445 mg/kg. The mean concentration of 4 elements was: 230.9± 1236.5, 21.1±67.14, 103.75±260.24, 9.4±17.6, for Zn, Se, Sr and Pb respectively. Ca phosphate had high concentration of these elements when compared to Oxalate and Urate stones. Zinc was found consistently in all types of stones. CONCLUSIONS Urinary stones contain high levels of many heavy metals within its components. Calcium based stones have the highest concentration of these elements. Heavy metals may substitute calcium and play a role in stone formation. Further spatial analysis is needed to localize the heavy metals within the stone lattice. Soil, water and food contamination could be a reason of heavy metal accumulation inside the stones. © 2015 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 193Issue 4SApril 2015Page: e377 Advertisement Copyright & Permissions© 2015 by American Urological Association Education and Research, Inc.MetricsAuthor Information Mahmoud El-Naggar More articles by this author Bedeir Ali-El-Dein More articles by this author Sanjeev Mehta More articles by this author Naimat Alsaigh More articles by this author Manoj Monga More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...