Abstract
INTRODUCTION AND OBJECTIVES:Sparse data exists regarding the impact of histological variants on survival outcomes in candidates to radical cystectomy (RC). We benefit from the largest multicenter collaboration available in the literature to evaluate incidence and impact on survival of histological variants at RC.METHODS:We focused on 2,332 patients treated with RC and pelvic lymph node dissection, between 1990 and 2018, at several American and European tertiary referral centers. All specimens were evaluated by dedicated uropatholgists. Univariable and multivariable competing risk regression analyses tested the effect off different histopathological findings on recurrence, cancer specific mortality (CSM) and overall mortality (OM).RESULTS:Overall, 296 (13%) and 527 (23%) patients were found with histological variants at TUR and RC, respectively. At TUR, considering histological variants, 19 (0.8%) were sarcomatoid, 2 (0.1%) lymphoepitelial, 17 (0.7%) small cell, 107 (4.6%) squamous, 22 (0.9%) micropapillar...
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