MP32-14 ELEVATED SERUM ESTRADIOL IS ASSOCIATED WITH HIGHER LIBIDO IN MEN ON TESTOSTERONE REPLACEMENT THERAPY

Abstract

You have accessJournal of UrologySexual Function/Dysfunction/Andrology: Evaluation1 Apr 2014MP32-14 ELEVATED SERUM ESTRADIOL IS ASSOCIATED WITH HIGHER LIBIDO IN MEN ON TESTOSTERONE REPLACEMENT THERAPY Ranjith Ramasamy, Jason Scovell, Jason Kovac, James Dupree, Gavin Langille, Dolores Lamb, and Larry Lipshultz Ranjith RamasamyRanjith Ramasamy More articles by this author , Jason ScovellJason Scovell More articles by this author , Jason KovacJason Kovac More articles by this author , James DupreeJames Dupree More articles by this author , Gavin LangilleGavin Langille More articles by this author , Dolores LambDolores Lamb More articles by this author , and Larry LipshultzLarry Lipshultz More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2014.02.944AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES The distinct roles of testosterone and estrogen on sexual function in men are controversial. We sought to determine the association of serum testosterone and estradiol with sexual satisfaction in men undergoing testosterone replacement therapy (TRT). METHODS Men with symptomatic hypogonadism (total testosterone < 300ng/dL) on TRT were asked to rate their quality of libido and strength of erections using a 5-point Likert Scale (1 = terrible to 5 = excellent). We evaluated sexual satisfaction in men with estradiol between 0.5-5.0 ng/dl and estradiol > 5.0 ng/dl and testosterone < 300 and > 300ng/dL. Serum hormones including follicle stimulating hormone (FSH), luteinizing hormone (LH), serum testosterone, and sex hormone binding globulin (SHBG) were collected on the same day that men reported their sexual domain satisfaction. Statistical analysis included t-test, chi-square, and ordinal logistic regression. We performed univariate and multivariate analysis to evaluate factors that predict libido and erectile strength. RESULTS A total of 423 men on TRT reported their sexual satisfaction. Men with serum testosterone > 300 reported a greater libido than men with testosterone < 300 (3.46 vs. 2.92, p<.01). Men with serum estradiol > 5 reported a greater libido than men with estradiol < 5 (3.70 vs. 3.23, p<.01). Men with serum testosterone > 300ng/dL and estradiol > 5 (n=91) were more likely to report a score of 4 or 5 on libido (60.4%) than men with testosterone < 300 and estradiol < 5 (31.3%, p<0.01). Univariate analysis showed an association between libido and age, FSH, LH, estradiol, and total testosterone. Interestingly, on multivariable analysis, only estradiol > 5 ng/dl (2.13, p=0.001) was associated with greater libido. None of the clinical parameters evaluated were associated with erectile strength. CONCLUSIONS Elevated estradiol is associated with a stronger libido in men on testosterone replacement. Estradiol and testosterone levels do not appear to be associated with erectile strength. © 2014FiguresReferencesRelatedDetails Volume 191Issue 4SApril 2014Page: e335 Advertisement Copyright & Permissions© 2014MetricsAuthor Information Ranjith Ramasamy More articles by this author Jason Scovell More articles by this author Jason Kovac More articles by this author James Dupree More articles by this author Gavin Langille More articles by this author Dolores Lamb More articles by this author Larry Lipshultz More articles by this author Expand All Advertisement Advertisement PDF DownloadLoading ...