MP32-03 ASSOCIATION BETWEEN SPECIFIC ASPECTS OF DIET AND INFLAMMATORY POTENTIAL AND BIOPSY UPGRADING IN MEN WITH PROSTATE CANCER ON ACTIVE SURVEILLANCE

Abstract

You have accessJournal of UrologyProstate Cancer: Epidemiology & Natural History II (MP32)1 Sep 2021MP32-03 ASSOCIATION BETWEEN SPECIFIC ASPECTS OF DIET AND INFLAMMATORY POTENTIAL AND BIOPSY UPGRADING IN MEN WITH PROSTATE CANCER ON ACTIVE SURVEILLANCE Zhuo Su, Mufaddal Mamawala, Mitchell Huang, Patricia Landis, Christian Pavlovich, Nitin Shivappa, Michael Wirth, James Hebert, and Bruce Trock Zhuo SuZhuo Su More articles by this author , Mufaddal MamawalaMufaddal Mamawala More articles by this author , Mitchell HuangMitchell Huang More articles by this author , Patricia LandisPatricia Landis More articles by this author , Christian PavlovichChristian Pavlovich More articles by this author , Nitin ShivappaNitin Shivappa More articles by this author , Michael WirthMichael Wirth More articles by this author , James HebertJames Hebert More articles by this author , and Bruce TrockBruce Trock More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000002036.03AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Diet has an important role in the regulation of chronic inflammation. However, there are limited data on whether diet and its inflammatory potential may affect the risk of disease reclassification for men with prostate cancer on active surveillance (AS). Therefore, we evaluated diet and inflammatory potential for their association with biopsy upgrading in men on AS. METHODS: The Johns Hopkins AS program is a prospective cohort of men with favorable risk prostate cancer managed with AS since 1995. Participants completed a survey about typical diet and supplement use at study entry. For each man we calculated the energy-adjusted dietary inflammatory index (E-DIITM) score based on an algorithm that estimated the inflammatory potential of his diet. Competing-risks regression assessed the association between daily intakes of 30 foods and nutrients vs. upgrading to Grade Group (GG) ≥2 on a surveillance biopsy, adjusting for E-DII, age, prostate-specific antigen density, positive biopsy cores, and body mass index at AS enrollment. To reduce the false discovery rate (FDR) from testing many diet/nutrient variables, we used the Benjamini–Hochberg procedure. RESULTS: This study included 1,227 men of whom 311 (25%) had biopsy upgrading to GG >2 over a median follow-up of 6 years. Higher daily intakes of dairy products (interquartile range 0.5-1.5 servings), calcium from food (0.5-0.9 g), calcium from food and supplements (0.5-1.1 g), gamma tocopherol from food (12-27 mg), and selenium from food and supplements (75-143 μg) were significantly associated with lower risk of biopsy upgrading. The subdistribution hazard ratio (sHR) for E-DII ranged from 0.93-0.97 and was not significant after FDR adjustment. After adjusting for FDR and clinical factors, selenium remained significantly associated with lower risk of upgrading: sHR=0.73 (95% CI: 0.61–0.88) (Table). CONCLUSIONS: In a large cohort of men with prostate cancer on AS we found higher intakes of dairy, calcium, gamma tocopherol and selenium to be associated with lower risk of biopsy upgrading, after adjusting for the diet’s inflammatory potential and clinical factors. Selenium remained significantly protective after controlling for FDR. Further research to confirm these findings and assess potential dose-response relationships is needed. Source of Funding: None © 2021 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 206Issue Supplement 3September 2021Page: e565-e565 Advertisement Copyright & Permissions© 2021 by American Urological Association Education and Research, Inc.MetricsAuthor Information Zhuo Su More articles by this author Mufaddal Mamawala More articles by this author Mitchell Huang More articles by this author Patricia Landis More articles by this author Christian Pavlovich More articles by this author Nitin Shivappa More articles by this author Michael Wirth More articles by this author James Hebert More articles by this author Bruce Trock More articles by this author Expand All Advertisement Loading ...