MP31-15 NOCTURIA WITH OR WITHOUT URGENCY

Abstract

INTRODUCTION AND OBJECTIVE: To investigate the relationship between urgency and the components of Metabolic syndrome (MetS), including obesity, hyperglycemia, hypertension, and dyslipidemia, in a residential population who had nocturia. METHODS: A cross-sectional questionnaire survey assessing the role of components of MetS on nocturia with urgency was conducted. We collected data on participants who participated in a multiphasic health screening, from April 2015 to March 2016, with written informed consent. All participants were asked to answer a self-reported questionnaire for OAB screening. One of the screening questions we used was “It is difficult to hold on when I have the sudden compelling desire to urinate” with a choice of the following two responses: yes or no. Participants who answered ‘yes’ were identified as having urgency. Nocturia was defined as 2 or more voids per night. We analyzed the relationship between urgency and age, gender, obesity, hyperglycemia, hypertension, and dyslipidemia among participants who had nocturia. The definitions of MetS and the components are consistent with the Japanese definition of metabolic syndrome. RESULTS: A total of 14,194 individuals aged 18-95 years participated in a multiphasic health screening. We excluded 1,716 participants (12.0%) with incomplete responses on the questionnaire, leaving a sample of 12,478 participants (5,313 men, 7,165 women). Participants’ median age was 69 years (range 18-95), and 3,570 (28.6%) participants had nocturia including 1,987 men (37.4%) and 1,583 women (22.1%). Participants who had nocturia with urgency had a significantly higher prevalence of obesity (37.3% vs 32.3%, p=0.020), hyperglycemia (37.5% vs 32.5%, p=0.012), dyslipidemia (42.0% vs 37.9%, p=0.046), and MetS (24.0% vs 18.8%, p=0.002), compared with those without urgency. In multivariate analysis, a significant association was found between urgency and the following: age, female (OR 1.58, 95%CI 1.33-1.88), obesity (1.34, 1.11-1.60), and hyperglycemia (1.20, 1.01-1.20) among participants with nocturia. A significant association was found between nocturia with urgency and MetS. The age and sex-adjusted odds ratio (95%CI) was 1.49 (1.22-1.82). CONCLUSIONS: Our study confirmed that individuals who report nocturia with urgency are more at risk of obesity, hyperglycemia, and MetS than those with nocturia without urgency. The combination of symptoms should prompt closer attention to cardiovascular health among primary care providers. Source of Funding: None.