MP31-06 MICRODISSECTION TESTICULAR SPERM EXTRACTION IS AN EFFECTIVE CHOICE TO OPTIMIZE FERTILITY OUTCOMES IN SEVERE OLIGOZOOSPERMIC PATIENTS WHO HAD PRIOR ONE OR MORE ASSISTED REPRODUCTIVE TECHNOLOGY FAILURE

Abstract

You have accessJournal of UrologyInfertility: Therapy (MP31)1 Sep 2021MP31-06 MICRODISSECTION TESTICULAR SPERM EXTRACTION IS AN EFFECTIVE CHOICE TO OPTIMIZE FERTILITY OUTCOMES IN SEVERE OLIGOZOOSPERMIC PATIENTS WHO HAD PRIOR ONE OR MORE ASSISTED REPRODUCTIVE TECHNOLOGY FAILURE Cheng-Han Tsai, Wei-Jen Chen, I-Shen Huang, Yi-Hsiu Huang, and William J. Huang Cheng-Han TsaiCheng-Han Tsai More articles by this author , Wei-Jen ChenWei-Jen Chen More articles by this author , I-Shen HuangI-Shen Huang More articles by this author , Yi-Hsiu HuangYi-Hsiu Huang More articles by this author , and William J. HuangWilliam J. Huang More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000002035.06AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: The aim of this study is to assess the fertility outcomes of intracytoplasmic sperm injection (ICSI) using testicular sperm retrieved by either conventional or microdissection testicular sperm extraction (cTESE or mTESE) in oligozoospermic men who failed to conceive their wives in prior assisted reproductive technology (ART) attempts using ejaculated sperm. METHODS: We retrospectively reviewed the charts of 32 oligozoospermic men who had failed one or more in vitro fertilization (IVF) or ICSI cycles using ejaculated sperm. They were categorized into 3 subgroups according to the sperm concentration: 5-20, 1-5 and <1 million/mL respectively. cTESE was done for all 3 groups. Nine patients in group <1 million/mL failed in the cTESE cycle and proceeded to mTESE. The sperm isolated were all used for ICSI. RESULTS: For these 32 patients, mean age was 38.9±5.4 years. Sperm retrieval rate was 100% in both groups. The female partners showed no difference in all groups. The overall fertilization rate per ICSI cycle was 64.8% and pregnancy rate was 46.9%. For patients underwent cTESE, the pregnancy rates were 75%, 18.2% and 15.4% for the group 5-20, 1-5 and <1 million/mL respectively. In 9 patients of <1 million/mL group, sperm retrieval was done by mTESE and the pregnancy rate was 55.6% (p=0.047, compared to cTESE in the <1 million/mL group). There was no complication occurred after testicular sperm extraction. CONCLUSIONS: Testicular sperm retrieval for ICSI is safe and results in much better pregnancy rates in oligozoospermic men who had prior one or more ART failure using ejaculated sperm. Furthermore, mTESE may be considered an effective choice to optimize ICSI outcomes in severe oligozoospermic patients. Source of Funding: None © 2021 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 206Issue Supplement 3September 2021Page: e557-e557 Advertisement Copyright & Permissions© 2021 by American Urological Association Education and Research, Inc.MetricsAuthor Information Cheng-Han Tsai More articles by this author Wei-Jen Chen More articles by this author I-Shen Huang More articles by this author Yi-Hsiu Huang More articles by this author William J. Huang More articles by this author Expand All Advertisement Loading ...