MP31-04 DOES INTRACYTOPLASMIC MORPHOLOGICALLY SELECTED SPERM INJECTION IMPROVE LIVE BIRTH RATES COMPARED TO ICSI IN MEN WITH INFERTILITY AND RAISED SPERM DNA FRAGMENTATION?

Abstract

You have accessJournal of UrologyInfertility: Therapy (MP31)1 Sep 2021MP31-04 DOES INTRACYTOPLASMIC MORPHOLOGICALLY SELECTED SPERM INJECTION IMPROVE LIVE BIRTH RATES COMPARED TO ICSI IN MEN WITH INFERTILITY AND RAISED SPERM DNA FRAGMENTATION? Runzhi Chen, Tharu Tharakan, Channa Jayasena, Sheena Lewis, Jaya Parikh, Meen-Yau Thum, James Nicopoullos, Tet Yap, and Suks Minhas Runzhi ChenRunzhi Chen More articles by this author , Tharu TharakanTharu Tharakan More articles by this author , Channa JayasenaChanna Jayasena More articles by this author , Sheena LewisSheena Lewis More articles by this author , Jaya ParikhJaya Parikh More articles by this author , Meen-Yau ThumMeen-Yau Thum More articles by this author , James NicopoullosJames Nicopoullos More articles by this author , Tet YapTet Yap More articles by this author , and Suks MinhasSuks Minhas More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000002035.04AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: There is conflicting evidence on the role of intracytoplasmic morphologically selected sperm injection (IMSI) in assisted reproductive technology (ART), and whether it increases live birth rates (LBR) compared to conventional intracytoplasmic sperm injection (ICSI). In particular, the role of IMSI on ART outcomes in infertile men with raised sperm DNA fragmentation (SDF) is controversial. METHODS: We performed a retrospective analysis of 2,693 ICSI and 765 IMSI cycles from a single institution. Primary outcome measures included fertilisation rate (FR), clinical pregnancy rate (CPR), miscarriage rate (MR), and live birth rates (LBR). Subgroup analysis was performed on couples who had undergone SDF testing with the Comet assay. Multiple regression analysis was performed to identify variables which may predict LBR in both the overall cohort of patients, and in the subgroup of patients with SDF data. An average Comet score (ACS) of ≥29% was used as the threshold for elevation, as previously defined. RESULTS: The LBR was comparable between ICSI and IMSI cycles in the overall study population; 18.1% and 21.0%, respectively. Subgroup analysis of men with a raised SDF (Table 1) demonstrated a lower MR (40.9% vs. 88.9%, p=0.003) and higher LBR (17.5% vs. 3.2%, p=0.003) in IMSI compared to ICSI cycles. No differences in clinical outcomes were observed between IMSI and ICSI cycles in men with a normal SDF. Multiple regression analysis revealed that IMSI significantly increased the probability of LBR (OR 7.052 [95% CI 1.826–27.237], p=0.005) in men with raised SDF. . . CONCLUSIONS: This study indicates that whilst IMSI may not be beneficial in the general infertile male population undergoing ART, it does improve LBR in men with raised SDF and male factor infertility. Source of Funding: N/A © 2021 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 206Issue Supplement 3September 2021Page: e556-e556 Advertisement Copyright & Permissions© 2021 by American Urological Association Education and Research, Inc.MetricsAuthor Information Runzhi Chen More articles by this author Tharu Tharakan More articles by this author Channa Jayasena More articles by this author Sheena Lewis More articles by this author Jaya Parikh More articles by this author Meen-Yau Thum More articles by this author James Nicopoullos More articles by this author Tet Yap More articles by this author Suks Minhas More articles by this author Expand All Advertisement Loading ...