MP29-04 GAIN OF CHROMOSOME 8Q IS ASSOCIATED WITH INFERIOR SURVIVAL IN PATIENTS WITH RENAL CELL CARCINOMA

Abstract

You have accessJournal of UrologyKidney Cancer: Basic Research II1 Apr 2014MP29-04 GAIN OF CHROMOSOME 8Q IS ASSOCIATED WITH INFERIOR SURVIVAL IN PATIENTS WITH RENAL CELL CARCINOMA Reza Mehrazin, Robert G. Uzzo, Essel Dulaimi, Karthik Devarjan, Jeffrey J. Tomaszewski, Joseph Testa, Jianming Pei, Philip Abbosh, Timothy Ito, Alexander Kutikov, and Tahseen Al-Saleem Reza MehrazinReza Mehrazin More articles by this author , Robert G. UzzoRobert G. Uzzo More articles by this author , Essel DulaimiEssel Dulaimi More articles by this author , Karthik DevarjanKarthik Devarjan More articles by this author , Jeffrey J. TomaszewskiJeffrey J. Tomaszewski More articles by this author , Joseph TestaJoseph Testa More articles by this author , Jianming PeiJianming Pei More articles by this author , Philip AbboshPhilip Abbosh More articles by this author , Timothy ItoTimothy Ito More articles by this author , Alexander KutikovAlexander Kutikov More articles by this author , and Tahseen Al-SaleemTahseen Al-Saleem More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2014.02.746AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES The proto-oncogene c-MYC, located on chromosome 8q, can be up-regulated through gain of 8q causing alteration in biology of renal cell carcinoma (RCC). The aim of this study was to evaluate the prevalence of chromosome 8q gain in our renal cancer tumor registry and to correlate findings with tumor histology, grade, cancer specific survival (CSS), and overall survival (OS) in clear and papillary METHODS Cytogenetic analysis by conventional or Chromosomal Microarray Analysis (CMA) was performed on tumors of 414 patients who underwent radical or partial nephrectomy for suspected RCC. Non-clear RCC, non-papillary RCC, and those which did not show alteration or gain in chromosome 8 on cytogenetic analysis were excluded from the study. Impact of gain in chromosome 8q status on CSS, OS, and its correlation with clinicopathological variables, obtained from our prospectively maintained kidney cancer database, were evaluated and compared to RCC’s that did not have gain in chromosome 8q. CSS and OS were assessed using log-rank test and the Cox proportional hazards model. RESULTS After the exclusions total 279 clear cell and papillary RCC tumors with cytogenetic analysis were included in study. Gain of 8q was detected in 18 (6.5%) tumors (9 clear cell, 3 sarcomatoid variant, and 6 papillary RCC), using either conventional method (11) or CMA (7). Gain of 8q was associated with higher grade (12% vs 2.0%, p = 0.001), higher risk of regional lymph node involvement (30 % vs. 6%, p=0.008), and distant metastasis (22 % vs. 4.0%, p<0.001). Among tumors with 8q gain, 56% were stage III or higher. No association between gain of 8q and age (p=0.23), sex (p=0.42), and CCI (p=0.59) was seen. Gain of chromosome 8q was associated with a 6.56 (95% CI, 3.06-14.05, p<0.0001) and 2.48 (95% CI, 1.33-5.92, p=0.007) fold decrease in CSS and OS, respectively, at a median follow-up of 56 months. CONCLUSIONS Chromosome 8q harbors the proto-oncogene c-MYC, which can be up regulated by gain of 8q. Our findings suggest that gain of 8q, shown by cytogenetics, can predict aggressive tumor phenotype and inferior survival in patients with RCC. These findings may help clinicians to identify high risk patients and enroll them into neoadjuvant and adjuvant clinical trials. © 2014FiguresReferencesRelatedDetails Volume 191Issue 4SApril 2014Page: e305-e306 Advertisement Copyright & Permissions© 2014MetricsAuthor Information Reza Mehrazin More articles by this author Robert G. Uzzo More articles by this author Essel Dulaimi More articles by this author Karthik Devarjan More articles by this author Jeffrey J. Tomaszewski More articles by this author Joseph Testa More articles by this author Jianming Pei More articles by this author Philip Abbosh More articles by this author Timothy Ito More articles by this author Alexander Kutikov More articles by this author Tahseen Al-Saleem More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...