MP29-10 INCREASED PREVALENCE OF URINARY TRACT INFECTIONS AND CATHETER-ASSOCIATED URINARY TRACT INFECTIONS IN DISORDERS CHARACTERIZED BY IRON DYSREGULATION

Abstract

You have accessJournal of UrologyInfections/Inflammation/Cystic Disease of the Genitourinary Tract: Kidney & Bladder II (MP29)1 Sep 2021MP29-10 INCREASED PREVALENCE OF URINARY TRACT INFECTIONS AND CATHETER-ASSOCIATED URINARY TRACT INFECTIONS IN DISORDERS CHARACTERIZED BY IRON DYSREGULATION Barbara Prol, Arrie Selva, Pamela Patton, Zhaoyi Chen, and Victoria Bird Barbara ProlBarbara Prol More articles by this author , Arrie SelvaArrie Selva More articles by this author , Pamela PattonPamela Patton More articles by this author , Zhaoyi ChenZhaoyi Chen More articles by this author , and Victoria BirdVictoria Bird More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000002026.10AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Urinary tract infection (UTI) accounts for up to 40% of all healthcare-associated infections and its prevalence varies among different populations. Bacteria require iron-rich environments for optimal survival. Escherichia coli (E. coli), the most common pathogen responsible for UTI, has been shown to thrive in iron-rich environments. Our aim was to explore the prevalence of UTI and catheter-associated urinary tract infection (CAUTI) in a cohort of patients with iron-sequestering disorders compared to other populations. METHODS: The University of Florida Health Informatics for Integrating Biology and the Bedside (i2b2) system was queried for the purpose of retrospective analysis of UTI and CAUTI associated with E. coli sepsis. International Classification Codes (ICD-9 and ICD-10) were used to obtain our target diagnoses of interest, subjects with the classically iron-wasting diseases: sickle cell anemia (SS), thalassemia (T), and hemochromatosis (H). Control groups included the general population (GP) and subjects with Crohn’s disease (CD) and ulcerative colitis (UC). Univariate analysis was performed. We used SASv.9.4 for our analysis. P-values were calculated in comparison with the GP. RESULTS: A total of 1.1 million patients from 2012-2018 were included in our data query. UTI prevalence in GP, CD and UC was 4.8%, 12.8% and 12.5%, respectively (p <0.0001 for CD and UC). CAUTI prevalence in GP, CD, and UC was 0.1%, 0.4%, and 0.6%, respectively (p <0.0001 for CD and UC). In comparison, UTI prevalence in SS, T, and H was 21.1%, 14.8% and 14.9%, respectively (p <0.0001 for SS, T, and H). CAUTI prevalence in SS and H was 0.9 and 0.7%, respectively (p <0.0001 for SS and H). The prevalence of E. coli sepsis in SS, H, T, UC, and CD was 1.3%, 0.4%, 0.3%, 0.4%, 0.3%, respectively, and 0.05% in GP (p <0.0004 for T; p <0.0001 for SS, H, UC, and CD). CONCLUSIONS: Both iron-sequestering and iron-deficient disorders have a significantly higher prevalence of UTI and CAUTI when compared to the GP. In particular, our data suggest that individuals with SS represent a vulnerable group susceptible to all: UTI, CAUTI, urosepsis, and E. coli-related septicemia. Iron imbalance is a novel risk factor for the development of UTI and related infections. Efforts aimed at prevention of UTI should be pursued in these high-risk groups and further research should be directed towards this phenomenon. Source of Funding: none © 2021 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 206Issue Supplement 3September 2021Page: e493-e493 Advertisement Copyright & Permissions© 2021 by American Urological Association Education and Research, Inc.MetricsAuthor Information Barbara Prol More articles by this author Arrie Selva More articles by this author Pamela Patton More articles by this author Zhaoyi Chen More articles by this author Victoria Bird More articles by this author Expand All Advertisement Loading ...