MP28-01 IMPACT OF SLEEP, PHYSICAL FUNCTION, AND PSYCHOSOCIAL FACTORS ON MALE LOWER URINARY TRACT SYMPTOMS: RESULTS FROM THE SYMPTOMS OF LOWER URINARY TRACT DYSFUNCTION RESEARCH NETWORK (LURN)

Abstract

You have accessJournal of UrologyBenign Prostatic Hyperplasia: Epidemiology & Evaluation (MP28)1 Sep 2021MP28-01 IMPACT OF SLEEP, PHYSICAL FUNCTION, AND PSYCHOSOCIAL FACTORS ON MALE LOWER URINARY TRACT SYMPTOMS: RESULTS FROM THE SYMPTOMS OF LOWER URINARY TRACT DYSFUNCTION RESEARCH NETWORK (LURN) Alexander Glaser, Sarah Mansfield, Abigail Smith, Brian Helfand, H. Henry Lai, Aruna Sarma, Claire Yang, Michelle Taddeo, J. Quentin Clemens, Anne Cameron, Kathryn Flynn, Victor Andreev, Matthew Fraser, Brad Erickson, Ziya Kirkali, and James Griffith Alexander GlaserAlexander Glaser More articles by this author , Sarah MansfieldSarah Mansfield More articles by this author , Abigail SmithAbigail Smith More articles by this author , Brian HelfandBrian Helfand More articles by this author , H. Henry LaiH. Henry Lai More articles by this author , Aruna SarmaAruna Sarma More articles by this author , Claire YangClaire Yang More articles by this author , Michelle TaddeoMichelle Taddeo More articles by this author , J. Quentin ClemensJ. Quentin Clemens More articles by this author , Anne CameronAnne Cameron More articles by this author , Kathryn FlynnKathryn Flynn More articles by this author , Victor AndreevVictor Andreev More articles by this author , Matthew FraserMatthew Fraser More articles by this author , Brad EricksonBrad Erickson More articles by this author , Ziya KirkaliZiya Kirkali More articles by this author , and James GriffithJames Griffith More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000002025.01AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Lower urinary tract symptoms (LUTS) are highly prevalent, decrease health-related quality of life (QOL), and are costly to treat. It is useful to consider storage symptoms, voiding symptoms, and urinary incontinence (UI) as separate sub-domains of LUTS, as they may dictate distinct treatment approaches. Although prior studies have demonstrated an association of anxiety/depression, physical activity, and sleep quality with LUTS, it remains unknown how these potentially modifiable factors influence various LUTS sub-domains in men. METHODS: Baseline data from 499 men in the LURN Observational Cohort study were analyzed to identify associations between PROMIS depression, anxiety, sleep disturbance, and physical function measures and LUTS sub-domains. LUTS sub-domains were derived from the AUA-Symptom Index and LUTS Tool. Multivariable linear regression was used to assess the relationships between PROMIS measures, participant characteristics and the LUTS sub-domains. PROMIS depression and anxiety measures were highly correlated (r=0.78); so only depression is described here. RESULTS: Depression was significantly associated with UI and voiding sub-domains (r=0.34 and 0.30, respectively, p <.01), while sleep disturbance was significantly associated with storage and voiding sub-domains (r=0.33 and 0.34, respectively, p <.01). Physical activity showed a smaller, but still significant, association with UI and storage sub-domains (r=-0.21 and -0.23, respectively, p <.01), but was not associated with voiding symptoms (r=-0.01, p=.79). AUA-SI QOL was significantly associated with sleep disturbance (r=0.37, p <.01), followed by depression (r=0.29, p <.01), but not physical function. Multivariable analyses (Figure) demonstrated that depression was strongly associated with UI, voiding symptoms, and QOL, while sleep quality showed a strong association with voiding and storage sub-domains and QOL. CONCLUSIONS: Urinary symptom sub-domains are independently associated with modifiable clinical variables including sleep quality and depression. Improved assessment and targeting of these non-urinary variables should be included as a priority in the care of men with LUTS. Source of Funding: This study is supported by the National Institute of Diabetes & Digestive & Kidney Diseases through cooperative agreements (grants DK097780, DK097772, DK097779, DK099932, DK100011, DK100017, DK099879) © 2021 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 206Issue Supplement 3September 2021Page: e480-e480 Advertisement Copyright & Permissions© 2021 by American Urological Association Education and Research, Inc.MetricsAuthor Information Alexander Glaser More articles by this author Sarah Mansfield More articles by this author Abigail Smith More articles by this author Brian Helfand More articles by this author H. Henry Lai More articles by this author Aruna Sarma More articles by this author Claire Yang More articles by this author Michelle Taddeo More articles by this author J. Quentin Clemens More articles by this author Anne Cameron More articles by this author Kathryn Flynn More articles by this author Victor Andreev More articles by this author Matthew Fraser More articles by this author Brad Erickson More articles by this author Ziya Kirkali More articles by this author James Griffith More articles by this author Expand All Advertisement Loading ...