MP27-15 THE IMPACT OF METABOLICALLY HEALTHY OBESITY IN PATIENTS PRESENTING FOR URO-ANDROLOGICAL DISORDERS: RESULTS FROM A CROSS SECTIONAL STUDY

Abstract

You have accessJournal of UrologySexual Function/Dysfunction: Evaluation I (MP27)1 Sep 2021MP27-15 THE IMPACT OF METABOLICALLY HEALTHY OBESITY IN PATIENTS PRESENTING FOR URO-ANDROLOGICAL DISORDERS: RESULTS FROM A CROSS SECTIONAL STUDY Walter Cazzaniga, Luca Boeri, Paolo Capogrosso, Giuseppe Fallara, Luigi Candela, Antonio Costa, Edoardo Pozzi, Federico Belladelli, Daniele Cignoli, Gianmarco Colandrea, Eugenio Ventimiglia, Massimiliano Raffo, Costantino Abbate, Francesco Montorsi, and Andrea Salonia Walter CazzanigaWalter Cazzaniga More articles by this author , Luca BoeriLuca Boeri More articles by this author , Paolo CapogrossoPaolo Capogrosso More articles by this author , Giuseppe FallaraGiuseppe Fallara More articles by this author , Luigi CandelaLuigi Candela More articles by this author , Antonio CostaAntonio Costa More articles by this author , Edoardo PozziEdoardo Pozzi More articles by this author , Federico BelladelliFederico Belladelli More articles by this author , Daniele CignoliDaniele Cignoli More articles by this author , Gianmarco ColandreaGianmarco Colandrea More articles by this author , Eugenio VentimigliaEugenio Ventimiglia More articles by this author , Massimiliano RaffoMassimiliano Raffo More articles by this author , Costantino AbbateCostantino Abbate More articles by this author , Francesco MontorsiFrancesco Montorsi More articles by this author , and Andrea SaloniaAndrea Salonia More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000002024.15AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: The role of metabolic syndrome (MetS) in men presenting for LUTS or ED has been broadly investigated. However limited evidence exists on the prevalence and the impact of metabolic healthy obesity (MHO) in these subsets of patients. We sought to evaluate the role of MHO on two cohorts of men evaluated primarily for LUTS or ED. METHODS: Complete socio-demographic and clinical data from 474 consecutive men evaluated for LUTS and 589 men evaluated for ED were analysed. Health-significant comorbidities were scored with the Charlson Comorbidity Index (CCI). The Harmonized International Diabetes Federation criteria (triglyceride level ≥150mg/dL; HDL cholesterol <40 mg/dL; systolic blood pressure ≥130 mmHG or diastolic blood pressure ≥85mmHG or blood pressure medications; fasting glucose ≥100 mg/dL or medications for diabetes; waist circumference of >102 cm) were used to define MetS. Based on BMI and MetS we defined four different groups: 1) metabolically healthy normal weight (MHN): BMI<30 without MetS; 2) metabolically unhealthy normal weight (MUN): BMI<30 with MetS; 3) metabolically healthy obesity (MHO): BMI ≥30 without MetS; and 4) metabolically unhealthy obesity (MUO): BMI ≥30 with MetS. The severity of ED was evaluated using the International Index of Erectile Function (IIEF) stratified according to Cappelleri’s criteria; LUTS severity was evaluated using the International Prostate Symptom Score (IPSS), with a total IPSS score >20 suggestive for severe symptoms. Multivariable logistic regression models (MVA), with age and CCI as covariates, explored the relationship between MHO and either LUTS or ED severity. RESULTS: In the LUTS cohort MHN, MUN, MHO and MUO was found in 407(85%), 30(6.3%), 25 (5.2%), 12 (2.5%) men, respectively. In the ED cohort, 497 (84.3%), 49 (8.3%), 25 (4.2%), 18 (3.7%) men had criteria suggestive for MHN, MUN, MHO and MUO, respectively. Except for metabolic parameters, no differences in term of clinical characteristics were observed among metabolic groups in both cohorts. Furthermore, MVA logistic regression analysis did not demonstrate an association between the severity of either LUTS or ED and MHO condition [OR: 0.98; 95%CI: 0.71–1.34; p=0.90 for LUTS, and OR: 1.05; 95%CI: 0.53-2.03; p=0.87 for ED] as compared with MHN. CONCLUSIONS: A non-negligible proportion of men primarily evaluated either for LUTS or ED exhibit a condition of MHO. Despite the prevalence, MHO seems not to be associated with the severity of symptoms in both cohorts. Source of Funding: None © 2021 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 206Issue Supplement 3September 2021Page: e477-e477 Advertisement Copyright & Permissions© 2021 by American Urological Association Education and Research, Inc.MetricsAuthor Information Walter Cazzaniga More articles by this author Luca Boeri More articles by this author Paolo Capogrosso More articles by this author Giuseppe Fallara More articles by this author Luigi Candela More articles by this author Antonio Costa More articles by this author Edoardo Pozzi More articles by this author Federico Belladelli More articles by this author Daniele Cignoli More articles by this author Gianmarco Colandrea More articles by this author Eugenio Ventimiglia More articles by this author Massimiliano Raffo More articles by this author Costantino Abbate More articles by this author Francesco Montorsi More articles by this author Andrea Salonia More articles by this author Expand All Advertisement Loading ...