MP27-03 EVALUATING THE IMPACT OF TIME BETWEEN RADICAL PROSTATECTOMY (RP) AND ADJUVANT RADIATION THERAPY (RT) ON ERECTILE FUNCTION RECOVERY (EFR)

Abstract

You have accessJournal of UrologySexual Function/Dysfunction: Evaluation I (MP27)1 Sep 2021MP27-03 EVALUATING THE IMPACT OF TIME BETWEEN RADICAL PROSTATECTOMY (RP) AND ADJUVANT RADIATION THERAPY (RT) ON ERECTILE FUNCTION RECOVERY (EFR) Jose M. Flores, Nicole Benfante, Elizabeth Schofield, and John P. Mulhall Jose M. FloresJose M. Flores More articles by this author , Nicole BenfanteNicole Benfante More articles by this author , Elizabeth SchofieldElizabeth Schofield More articles by this author , and John P. MulhallJohn P. Mulhall More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000002024.03AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: RT post-RP in men with PSA recurrence improves survival. It is also associated with a higher rate of urinary incontinence and erectile dysfunction (ED). We attempted to evaluate if the time period between RP and adjuvant RT predicts EFR outcomes. METHODS: Men who received RT post-RP with ≥2 years post-RT follow-up were analyzed. ADT and RT pre-RP were exclusions. Demographics, comorbidities and pathological parameters and IIEF erectile function domain (EFD) scores were recorded. We report median EFD scores and factors correlated with EFR ≥24 months post-RT. Factors included: patient age, comorbidities, smoking status, baseline pre-RP and pre-RT Testosterone (T), prostate specific antigen (PSA), baseline EFD score, Nerve-Vascular bundle (NVB) status, and time between RP and RT. RESULTS: 126 men were included. Mean age at RP was 63±7 years. Mean pre-RP T was 390±222 ng/dL, PSA, 10.2±10.4 ng/mL and median EFD score were 27 (IQR=20–30). Median pre-RT T was 376.9±187 ng/dL, PSA 0.25±0.33 ng/mL, and median EFD score was 9 (IQR = 3–20). 54% of patients had bilateral NVB preservation, and 29.5% unilateral. 71% received ADT with their RT, the median duration of ADT exposure was 4.5 (IQR = 3–8.5) months. Median time between RP and RT was 14.9 months (IQR = 8.5–28.6) months; 41% had ≤1 year between RP and RT. 2 years post RT, median EFD was 9.5 (IQR = 3–22). 22% had a score ≥24. EFD score at follow-up was correlated with age at RP (r=-0.32, p<0.001), and pre-RT EFD score (r=0.56, p<0.001). Time between RP and RT did not correlate with EFD score at follow up (r=0.08, p=0.39). CONCLUSIONS: In our prostate cancer patients cohort post-RP/RT, EFR is lower; almost 4 of 5 patients will have some ED degree at two years post-RT. The period time between RP and RT is not correlated with EFR post-RT. Source of Funding: None © 2021 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 206Issue Supplement 3September 2021Page: e472-e473 Advertisement Copyright & Permissions© 2021 by American Urological Association Education and Research, Inc.MetricsAuthor Information Jose M. Flores More articles by this author Nicole Benfante More articles by this author Elizabeth Schofield More articles by this author John P. Mulhall More articles by this author Expand All Advertisement Loading ...