MP26-10 PATERNAL CANCER HISTORY DOES NOT INCREASE OBSTETRIC COMPLICATIONS

Abstract

You have accessJournal of UrologyInfertility: Epidemiology & Evaluation I (MP26)1 Apr 2020MP26-10 PATERNAL CANCER HISTORY DOES NOT INCREASE OBSTETRIC COMPLICATIONS Kelli Gross*, Huong Meeks, Deepika Garg, Darshan Patel, Alexander Pastuszak, Heidi Hanson, Ken Smith, Joseph Letourneau, and James Hotaling Kelli Gross*Kelli Gross* More articles by this author , Huong MeeksHuong Meeks More articles by this author , Deepika GargDeepika Garg More articles by this author , Darshan PatelDarshan Patel More articles by this author , Alexander PastuszakAlexander Pastuszak More articles by this author , Heidi HansonHeidi Hanson More articles by this author , Ken SmithKen Smith More articles by this author , Joseph LetourneauJoseph Letourneau More articles by this author , and James HotalingJames Hotaling More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000000865.010AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Paternal factors such as epigenetic changes and DNA damage have an effect on the fetal environment, including risk of preterm birth and intrauterine growth retardation in animal models. Our objective was to determine if men previously treated for cancer were more likely to father children with pregnancy related complications. METHODS: A retrospective, matched case-control analysis was performed using the Utah Population Database to compare obstetric complications of children born by male cancer patients with children born by their matched controls A total of 21,389 male Utah residents diagnosed between 1956 and 2013 were identified. We excluded patients who were diagnosed with cancer prior to 18 years old, patients who did not have a child prior to and after first cancer diagnosis, and those who could not be matched to controls. We included 732 cancer patients in the analysis who were matched to 1,251 controls by birth year, whether born in or out of Utah, and time residing in Utah. Obstetric complications for their children were compared between cancer cases and their matching controls. Conditional logistic regression was performed to estimate the association between prior cancer diagnosis in males and birth outcomes in their offspring, additionally adjusted for race and ethnicity. RESULTS: There were no significant differences in the number of live births prior to first cancer diagnosis, with 1.9 ± 1.2 live births for cancer patients and 1.9 ± 1.1 for controls (p=0.930) being observed. No significant differences in rates of the patient’s female partner having a pregnancy with eclampsia, preeclampsia, pregnancy induced hypertension, HELLP syndrome (hemolysis, elevated liver enzymes, low platelet count), HTP, preterm delivery, congenital malformations, labor complications, very low birth weight live birth, low birth weight live birth, Cesarean section delivery, or Apgar score <7 at 1 or 5 minutes were observed (Table 1). CONCLUSIONS: Children conceived after paternal cancer treatment are not at increased risk of obstetric complications. Source of Funding: None © 2020 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 203Issue Supplement 4April 2020Page: e404-e404 Advertisement Copyright & Permissions© 2020 by American Urological Association Education and Research, Inc.MetricsAuthor Information Kelli Gross* More articles by this author Huong Meeks More articles by this author Deepika Garg More articles by this author Darshan Patel More articles by this author Alexander Pastuszak More articles by this author Heidi Hanson More articles by this author Ken Smith More articles by this author Joseph Letourneau More articles by this author James Hotaling More articles by this author Expand All Advertisement PDF downloadLoading ...