MP26-08 MAGNETIC RESONANCE IMAGING-TARGETED BIOPSY FOR PRIMARY DETECTION OF PROSTATE CANCER: MRI IN-BORE VERSUS MRI-TRUS FUSION TECHNIQUE PERFORMED BY THE SAME OPERATORS' TEAM

Abstract

You have accessJournal of UrologyProstate Cancer: Detection & Screening II (MP26)1 Sep 2021MP26-08 MAGNETIC RESONANCE IMAGING-TARGETED BIOPSY FOR PRIMARY DETECTION OF PROSTATE CANCER: MRI IN-BORE VERSUS MRI-TRUS FUSION TECHNIQUE PERFORMED BY THE SAME OPERATORS' TEAM Martina Pecoraro, Francesco Del Giudice, Riccardo Campa, Maurizio Del Monte, Emanuele Messina, Marco Bicchetti, Alessandro Sciarra, Carlo Catalano, and Valeria Panebianco Martina PecoraroMartina Pecoraro More articles by this author , Francesco Del GiudiceFrancesco Del Giudice More articles by this author , Riccardo CampaRiccardo Campa More articles by this author , Maurizio Del MonteMaurizio Del Monte More articles by this author , Emanuele MessinaEmanuele Messina More articles by this author , Marco BicchettiMarco Bicchetti More articles by this author , Alessandro SciarraAlessandro Sciarra More articles by this author , Carlo CatalanoCarlo Catalano More articles by this author , and Valeria PanebiancoValeria Panebianco More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000002023.08AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: (I) To compare the difference in the detection of overall PCa and csPCa between MRI-guided In-bore and MRI-TRUS targeted biopsy (TBx), performed by the same operators’ team. (II) To compare the two MR-directed biopsy (MRDB) techniques in terms of median percentage of cancer per biopsy core. METHODS: Retrospective single-center study. 263 patients enrolled. Prostate mpMRI was performed for the entire cohort. MRDB was performed when a PI-RADS score ≥3 was reported. For PCa and csPCa detection rate (DR), 2x2 contingency tables were tested via the Pearson’s chi-squared to explore the variance of the outcome distribution. The % of positive malignant cores was tested with a two-tailed Mann-Withney test.A multivariable logistic regression model was developed to assess the relative influence of MRI-TRUS vs. In-Bore TBx for both the outcome of PCa and csPCa diagnosis. Moreover, according to available literature and to the cohort quantitative descriptive distribution, after having assumed, as per secondary outcome, a relevant threshold of neoplastic median per-core percentage ≥50%, we implemented the same regression model to test the ability of one technique over the other to better characterize the overall sampled tumor tissue within the biopsy cores. RESULTS: Overall, per-patient PCa and csPCa detection rate was 140/223 (62.8%) and 97/223 (43.5%), respectively. PCa-DR was 73/117 (62.4%) and 67/106 (63.2%) for MRI-TRUS and MRI In-Bore TBx (p=0.9), while csPCa detection rate reached 50/117 (42.7%) and 47/106 (44.3%), respectively (p=0.81). The median overall per-patient percentage of malignant tissue within the total biopsy cores was 50% (IQR: 27–65%) for PCa and 60% (IQR: 35–68%) for csPCa, with a significant discrepancy between the two techniques. MRI In-Bore TBx was independently associated with more than 3-fold ability to reach the outcome in the case of PCa but not for csPCa (ORPCa: 3.34, 95%CI: 1.46–7.6, and ORcsPCa: 2.21, 95%CI: 0.86–5.7 respectively). CONCLUSIONS: No statistically significant difference was detected in terms of cancer DR comparing MRI In-Bore and TRUS TBx. MRI-TB showed highest per-core malignant cells percentage and lower mean volume of the targets compared to MRI-TRUS TBx. Source of Funding: None © 2021 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 206Issue Supplement 3September 2021Page: e465-e465 Advertisement Copyright & Permissions© 2021 by American Urological Association Education and Research, Inc.MetricsAuthor Information Martina Pecoraro More articles by this author Francesco Del Giudice More articles by this author Riccardo Campa More articles by this author Maurizio Del Monte More articles by this author Emanuele Messina More articles by this author Marco Bicchetti More articles by this author Alessandro Sciarra More articles by this author Carlo Catalano More articles by this author Valeria Panebianco More articles by this author Expand All Advertisement Loading ...