MP26-04 OVER THE COUNTER ANTIBIOTICS? EFFECTS ON ESCHERICHIA COLI INCIDENCE AND RESISTANCE IN UNCOMPLICATED URINARY TRACT INFECTIONS IN JORDAN

Abstract

You have accessJournal of UrologyInfections/Inflammation/Cystic Disease of the Genitourinary Tract: Kidney & Bladder II1 Apr 2016MP26-04 OVER THE COUNTER ANTIBIOTICS? EFFECTS ON ESCHERICHIA COLI INCIDENCE AND RESISTANCE IN UNCOMPLICATED URINARY TRACT INFECTIONS IN JORDAN Zeid AbuGhosh, Mohammad Alsadi, Fares Ayoub, Montaser Alhakim, and Tala Alnawaji Zeid AbuGhoshZeid AbuGhosh More articles by this author , Mohammad AlsadiMohammad Alsadi More articles by this author , Fares AyoubFares Ayoub More articles by this author , Montaser AlhakimMontaser Alhakim More articles by this author , and Tala AlnawajiTala Alnawaji More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2016.02.2941AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Antibiotics are readily available over the counter in Jordan and self-treatment of infections is a common practice. The effects of this health behavior on local microbial resistance and incidence of different microbes in uncomplicated Urinary Tract Infections (UTI) has not been investigated. Current American Urological Association (AUA) treatment guidelines for uncomplicated UTI recommend a 3-day course of Trimethoprim/Sulfamethoxazole (TMP/SMX) if resistance is less than 20% and the usage of a Fluoroquinolone if resistance is higher. We sought to evaluate how the availability of antibiotics over the counter has affected the incidence of E. Coli and its resistance to recommended antibiotics in AUA guidelines. METHODS We conducted an electronic health record review of 27313 urine cultures submitted through the Jordanian national electronic health database, Hakeem, at three participating hospitals, between January 1st 2011 and April 30th 2015. The data was analyzed to determine positive cultures associated with a diagnosis of uncomplicated UTI, the incidence of E. Coli and its resistance to antibiotics recommended in AUA guidelines. RESULTS Overall, 2307 samples grew bacterial isolates at >105 colony forming units and were associated with a diagnosis of uncomplicated UTI. Of those, (1769, 76.7%) cultures grew E. Coli. Resistance to TMP/SMX was (69.63%), Levofloxacin (47.35%), Ciprofloxacin (20.08%), and Nitrofurantoin (9.94%). CONCLUSIONS The resistance of E. coli to TMP/SMX and Levofloxacin is much higher than reported international rates. This can be explained by their availability over the counter and the high rates of patient self-treatment in Jordan. E. Coli exhibited the least resistance to Nitrofurantoin, making it an effective and cost-effective first choice antibiotic for uncomplicated UTI in Jordan. Our data emphasizes the urgent need for healthcare policy changes towards over the counter antibiotic marketing and the need for locally tailored guidelines for the management of uncomplicated UTIs. © 2016FiguresReferencesRelatedDetails Volume 195Issue 4SApril 2016Page: e355 Advertisement Copyright & Permissions© 2016MetricsAuthor Information Zeid AbuGhosh More articles by this author Mohammad Alsadi More articles by this author Fares Ayoub More articles by this author Montaser Alhakim More articles by this author Tala Alnawaji More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...