MP25-18 DOES DIABETES MELLITUS AFFECT THE RECOVERY OF RENAL DYSFUNCTION FOLLOWING REVERSIBLE UNILATERAL URETERIC OBSTRUCTION?

Abstract

You have accessJournal of UrologyStone Disease: Basic Research II1 Apr 2014MP25-18 DOES DIABETES MELLITUS AFFECT THE RECOVERY OF RENAL DYSFUNCTION FOLLOWING REVERSIBLE UNILATERAL URETERIC OBSTRUCTION? Fayez Hammad, Omran Bakoush, and Loay Lubbad Fayez HammadFayez Hammad More articles by this author , Omran BakoushOmran Bakoush More articles by this author , and Loay LubbadLoay Lubbad More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2014.02.320AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Following reversal of relatively short periods of unilateral ureteral obstruction (UUO), renal functional parameters such as renal blood flow (RBF), glomerular filtration rate (GFR), urinary volume (UV), total (UNaV) and fractional (FENa) excretion of sodium ultimately recover within a certain time frame. Diabetic mellitus (DM) might result in renal damage. Hence, it is possible that the ability of the diabetic kidney to recover from UUO is impaired. Thus, the aim of this study was to examine the renal functional changes following reversal of UUO in diabetic rats. METHODS Diabetes mellitus (DM) was induced by intraperitoneal injection of streptozotocin in Wistar rats which then received daily insulin for 3 months to maintain blood glucose level between 18-25 mM. All diabetic rats and age-matched controls underwent reversible 24-hour left UUO. The renal functions of right and left kidneys were studied using clearance techniques, 3 hours (Group N-1 and D-1), 7 days (Group N-2 and D-2) and 30 days (Group N-3 and D-3) following reversal of UUO. Group N-1, N-2 and N-3 were normal rats whereas group D-1, D-2 and D-3 were diabetic rats. The right non-obstructed kidney was used as a control for the left obstructed kidney. RESULTS In group N-1, GFR and RBF of the left kidney were 30% and 52% of the right kidney, respectively (P<0.05 for both). However, the FENa was higher in the left kidney (232%, P=0.06). In group N-2, the left GFR was still marginally lower than the right GFR (74%, P=0.052) but all other parameters were similar in both kidneys. In group N-3, all left and right parameters were similar. CONCLUSIONS In this model of 24-hr reversible UUO, all hemodynamic and tubular renal parameters were significantly altered shortly after reversal. In diabetes, although, there was a trend in some of the parameters to deteriorate more significantly shortly after the reversal, all of them returned back to baseline by 30 days post-reversal similar to normal subjects. © 2014FiguresReferencesRelatedDetails Volume 191Issue 4SApril 2014Page: e273-e274 Advertisement Copyright & Permissions© 2014MetricsAuthor Information Fayez Hammad More articles by this author Omran Bakoush More articles by this author Loay Lubbad More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...