MP25-12 HANDHELD OPTICAL DEVICE DETECTS BACTERIURIA AND CATHETER-ASSOCIATED URINARY TRACT INFECTION

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You have accessJournal of UrologyInfections/Inflammation/Cystic Disease of the Genitourinary Tract: Kidney & Bladder I (MP25)1 Sep 2021MP25-12 HANDHELD OPTICAL DEVICE DETECTS BACTERIURIA AND CATHETER-ASSOCIATED URINARY TRACT INFECTION Rena Malik, and Rajagopal Srinivasan Rena MalikRena Malik More articles by this author , and Rajagopal SrinivasanRajagopal Srinivasan More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000002022.12AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Traditional diagnostic tests cannot discriminate asymptomatic bacteriuria (ASB) from catheter-associated urinary tract infection (CAUTI). High false-positive rates with current tests lead to excessive antibiosis, drug resistance, and worse outcomes in the chronically-catheterized. We are evaluating a handheld optical device’s ability to distinguish ASB from CAUTI. METHODS: normal, POSitive (confirmed UTI), and COLonized catheters with varying rates of ASB. Spectra were analyzed using principal component analysis (PCA). RESULTS: Of 68 specimens, 37 were classified beyond reasonable doubt by physician review of clinical details and culture results. 18 were NEG, 5 were POS, and 14 were COL. Mean spectra and standard deviations for each category are plotted in Fig. 1. PCA reveals clustering of POS, NEG, and COL signals (Fig. 2). Using a simple discriminant along the horizontal axis, sensitivity is 80% and specificity is 91%. CONCLUSIONS: Spectroscopy can predict negative culture results and help distinguish ASB from CAUTI. Source of Funding: Investigators were supported by grants from UMEMA PA and Maryland Innovation Initiative. © 2021 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 206Issue Supplement 3September 2021Page: e457-e458 Advertisement Copyright & Permissions© 2021 by American Urological Association Education and Research, Inc.MetricsAuthor Information Rena Malik More articles by this author Rajagopal Srinivasan More articles by this author Expand All Advertisement Loading ...