Abstract
INTRODUCTION AND OBJECTIVES:Previous studies reported that presurgical treatment with molecular targeted drug reduced operation risk by downsizing of tumor thrombus in patients with advanced renal cell carcinoma (RCC) with inferior vena cava tumor thrombus. We evaluated improvement of surgical outcome of resection both tumor and thrombus.METHODS:A retrospective chart review of 42 patients who was operated for advanced RCC with inferior vena cava tumor thrombus at Kobe University Hospital from March 2008 to September 2018 was performed. We investigated surgical outcome of patients who received presurgical treatment by compared with surgery alone. We used pazopanib for presurgical treatment and MAYO classification for decision of tumor thrombus level.RESULTS:Six patients received presurgical treatment before surgery and remaining 36 patients were treated with surgery alone. In presugical group there were 3 patients with level 3 thrombus and 3 patients with level 4 thrombus. In surgery alone group there were...
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