Abstract
INTRODUCTION AND OBJECTIVES:Prostate cancer remains one of the most common cancer diagnoses among men worldwide, and the risk stratification system between indolent and aggressive disease continues to evolve. Radical prostatectomy surgery (RP) is a common curative treatment option, but incontinence and erectile dysfunction are frequent side effects of the procedure. As 30-40% of low-grade patients are upgraded to higher grade at RP, many patients choose RP treatment even though they harbor indolent disease. We have previously established a serum microRNA signature that predicts prostate cancer aggressiveness in order to further stratify patients and potentially help guide treatment decisions. Our current goals are to 1) validate the serum microRNA signature in a larger cohort and 2) determine if this prognostic signature is further enriched in circulating serum exosomes. Our hypothesis is that circulating exosomes harbor an enriched microRNA prognostic signature due to selective secretion from the prostat...
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