MP23-16 ULTIMATE FATE OF RECURRENT CYSTITIS CAUSED BY ESBL-PRODUCING E.COLI; A PROSPECTIVE LONGITUDINAL STUDY

Abstract

You have accessJournal of UrologyInfections/Inflammation/Cystic Disease of the Genitourinary Tract: Kidney & Bladder II1 Apr 2018MP23-16 ULTIMATE FATE OF RECURRENT CYSTITIS CAUSED BY ESBL-PRODUCING E.COLI; A PROSPECTIVE LONGITUDINAL STUDY Sun Tae Ahn, Hyeong Guk Jeong, Tae Yong Park, Jong Wook Kim, Hong Seok Park, Du Geon Moon, Jeong Gu Lee, and Mi Mi Oh Sun Tae AhnSun Tae Ahn More articles by this author , Hyeong Guk JeongHyeong Guk Jeong More articles by this author , Tae Yong ParkTae Yong Park More articles by this author , Jong Wook KimJong Wook Kim More articles by this author , Hong Seok ParkHong Seok Park More articles by this author , Du Geon MoonDu Geon Moon More articles by this author , Jeong Gu LeeJeong Gu Lee More articles by this author , and Mi Mi OhMi Mi Oh More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2018.02.748AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Urinary tract infections (UTIs) caused by extended-spectrum β-lactamase (ESBL)-producing Escherichia coli (E.coli) have become a serious health concern worldwide due to their multidrug-resistance with seriously limiting therapeutic options. There were numerous studies on risk factors for development of ESBL-producing E.coli; however the long-term ultimate fate of UTIs caused by ESBL-producing E.coli remains unknown. Thus, here in we longitudinally monitored female patients with UTIs due to ESBL-producing E.coli and evaluated the recurrence rate and causative organism once UTI recurred during follow up. METHODS Between Jan 2014 and Dec 2014, we enrolled the female patients with UTIs caused by ESBL-producing E.coli, and each patient was followed up 24 months longitudinally. Clinical and microbiological data were collected. During observation period, we investigated the recurrence rate per se and recurrence rate of UTIs due to ESBL producing E.coli. Also we evaluated the risk factors for recurrence of UTIs due to ESBL producing UTIs during follow up. RESULTS Among 127 patients who were enrolled initially, total 106 patients complete the study. Total 45 (45/106, 42.5%) patients experienced UTI recur during observation period and among those patients 34 (34/45, 75.6%) patients recurred with ESBL-producing E.coli. The recurrences with ESBL-producing E.coli were more frequent in patients who had history of cephalosporin use (Table 1). In multivariate analysis, history of cephalosporin use was independent risk factors of recurrence UTIs with ESBL-producing E.coli compared with those who recurred with ESBL negative E.coli (OR 12.92, Cl 1.45-115.6, P=0.022) CONCLUSIONS About 75% of patients initially caused by ESBL producing E.coli recurred with ESBL producing E.coli during follow up. The history of cephalosporin use was identified as the risk factor of UTI recurrence caused by ESBL-producing E.coli in our cohort. Thus, recurrent cystitis patients who have the history of cephalosporin use and UTIs with ESBL-producing E.coli are warranted to be treated base on antibiotic susceptibility profiles of the previous ESBL-producing E.coli. © 2018FiguresReferencesRelatedDetails Volume 199Issue 4SApril 2018Page: e287 Advertisement Copyright & Permissions© 2018MetricsAuthor Information Sun Tae Ahn More articles by this author Hyeong Guk Jeong More articles by this author Tae Yong Park More articles by this author Jong Wook Kim More articles by this author Hong Seok Park More articles by this author Du Geon Moon More articles by this author Jeong Gu Lee More articles by this author Mi Mi Oh More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...