MP23-11 PERIOPERATIVE COMPLICATIONS AFTER RADICAL CYSTECTOMY FOR BLADDER CANCER: AN INTERNATIONAL MULTICENTER COLLABORATION

Abstract

You have accessJournal of UrologyCME1 May 2022MP23-11 PERIOPERATIVE COMPLICATIONS AFTER RADICAL CYSTECTOMY FOR BLADDER CANCER: AN INTERNATIONAL MULTICENTER COLLABORATION Chiara Lonati, Luca Afferi, Ettore Di Trapani, Stefania Zamboni, Claudio Simeone, Alberto Briganti, Francesco Montorsi, Giuseppe Simone, Francesco Soria, M. Carmen Mir, Rafael Sanchez-Salas, Mathieu Roumiguié, Alessandro Antonelli, Kees Hendricksen, Agostino Mattei, Christian D. Fankhauser, Roberto Carando, Jeremy Y.C. Teoh, Shahrokh F. Shariat, Simone Albisinni, Rodolfo Hurle, Angelo Peroni, Evanguelos Xylinas, Wojciech Krajewski, Morgan Roupret, and Marco Moschini Chiara LonatiChiara Lonati More articles by this author , Luca AfferiLuca Afferi More articles by this author , Ettore Di TrapaniEttore Di Trapani More articles by this author , Stefania ZamboniStefania Zamboni More articles by this author , Claudio SimeoneClaudio Simeone More articles by this author , Alberto BrigantiAlberto Briganti More articles by this author , Francesco MontorsiFrancesco Montorsi More articles by this author , Giuseppe SimoneGiuseppe Simone More articles by this author , Francesco SoriaFrancesco Soria More articles by this author , M. Carmen MirM. Carmen Mir More articles by this author , Rafael Sanchez-SalasRafael Sanchez-Salas More articles by this author , Mathieu RoumiguiéMathieu Roumiguié More articles by this author , Alessandro AntonelliAlessandro Antonelli More articles by this author , Kees HendricksenKees Hendricksen More articles by this author , Agostino MatteiAgostino Mattei More articles by this author , Christian D. FankhauserChristian D. Fankhauser More articles by this author , Roberto CarandoRoberto Carando More articles by this author , Jeremy Y.C. TeohJeremy Y.C. Teoh More articles by this author , Shahrokh F. ShariatShahrokh F. Shariat More articles by this author , Simone AlbisinniSimone Albisinni More articles by this author , Rodolfo HurleRodolfo Hurle More articles by this author , Angelo PeroniAngelo Peroni More articles by this author , Evanguelos XylinasEvanguelos Xylinas More articles by this author , Wojciech KrajewskiWojciech Krajewski More articles by this author , Morgan RoupretMorgan Roupret More articles by this author , and Marco MoschiniMarco Moschini More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000002562.11AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: To evaluate incidence of perioperative complications after radical cystectomy (RC) for bladder cancer (BCa), assessing risk factors for intra- and post-operative complications. METHODS: We retrospectively analyzed data of 4,731 patients treated with RC for BCa among 25 tertiary referral centers between 2001 and 2020. Intra-operative complications included gastrointestinal (GI), vascular, nerve injury, position-related skin and peripheral nerve lesion, and death. Post-operative complications were coded as early (<30 days) and late (30-90 days) complications, including infectious, GI, genitourinary (GU), hematological, cardiac, wound complications, and death. Multivariable logistic regression models (LGRs) were applied to evaluate independent predictors of intra- and post-operative complications; covariates consisted of demographic features and perioperative outcomes. RESULTS: Open, laparoscopic, and robotic RC were performed in 69.1%, 10.7%, 20.2% of patients, respectively; conversion from robotic to open technique was recorded in 3 patients. Overall, 3.8% of patients experienced intra-operative complications: vascular injury occurred in 40.6% of cases, followed by GI injury (32.8%); intra-operative death occurred in 1.1% of cases (Fig. 1A). Overall, 64.1% of patients experienced post-operative complications (early: 57.6% and late: 17.9%). Infectious complications occurred in 26% of patients, followed by anemia (20.3%), and GI (18.3%) complications. Death due to early and late complications occurred in 1.5% and 0.6% of patients, respectively (Fig. 1B). At multivariable LGMs prior abdominal surgery (odd ratio [OR]: 1.87; p=0.005) and surgeon experience (>250 RC/surgeon: OR: 0.27; p=0.003) were independent predictors of intra-operative complications, while female gender (OR: 0.66; p=0.03), anticoagulant therapy (OR: 2.05; p=0.04), and post-operative transfusions (OR: 4.84; p <0.001) were independent predictors of post-operative complications. Surgical RC technique was not an independent predictor of complication. CONCLUSIONS: RC is still burden with an increased rate of perioperative complications. Risk factors for perioperative complications include scarce surgeon experience, prior abdominal surgery, and post-operative transfusions. Source of Funding: None © 2022 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 207Issue Supplement 5May 2022Page: e385 Advertisement Copyright & Permissions© 2022 by American Urological Association Education and Research, Inc.MetricsAuthor Information Chiara Lonati More articles by this author Luca Afferi More articles by this author Ettore Di Trapani More articles by this author Stefania Zamboni More articles by this author Claudio Simeone More articles by this author Alberto Briganti More articles by this author Francesco Montorsi More articles by this author Giuseppe Simone More articles by this author Francesco Soria More articles by this author M. Carmen Mir More articles by this author Rafael Sanchez-Salas More articles by this author Mathieu Roumiguié More articles by this author Alessandro Antonelli More articles by this author Kees Hendricksen More articles by this author Agostino Mattei More articles by this author Christian D. Fankhauser More articles by this author Roberto Carando More articles by this author Jeremy Y.C. Teoh More articles by this author Shahrokh F. Shariat More articles by this author Simone Albisinni More articles by this author Rodolfo Hurle More articles by this author Angelo Peroni More articles by this author Evanguelos Xylinas More articles by this author Wojciech Krajewski More articles by this author Morgan Roupret More articles by this author Marco Moschini More articles by this author Expand All Advertisement PDF DownloadLoading ...