MP22-07 WHAT IS APPROPRIATE DEFINITION OF IPSS RESOLUTION WHICH CORRELATES CLOSELY WITH QOL RECOVERY AFTER PROSTATE BRACHYTHERAPY?

Abstract

You have accessJournal of UrologyProstate Cancer: Localized: Radiation Therapy1 Apr 2018MP22-07 WHAT IS APPROPRIATE DEFINITION OF IPSS RESOLUTION WHICH CORRELATES CLOSELY WITH QOL RECOVERY AFTER PROSTATE BRACHYTHERAPY? Hidehisa Mori, Tomoharu Fukumori, Kei Daizumoto, Keisuke Ozaki, Yoshito Kusuhara, Tomoya Fukawa, Yasuyo Yamamoto, Kunihisa Yamaguchi, Masayuki Takahashi, and Hiro-omi Kanayama Hidehisa MoriHidehisa Mori More articles by this author , Tomoharu FukumoriTomoharu Fukumori More articles by this author , Kei DaizumotoKei Daizumoto More articles by this author , Keisuke OzakiKeisuke Ozaki More articles by this author , Yoshito KusuharaYoshito Kusuhara More articles by this author , Tomoya FukawaTomoya Fukawa More articles by this author , Yasuyo YamamotoYasuyo Yamamoto More articles by this author , Kunihisa YamaguchiKunihisa Yamaguchi More articles by this author , Masayuki TakahashiMasayuki Takahashi More articles by this author , and Hiro-omi KanayamaHiro-omi Kanayama More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2018.02.718AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES We previously reported that International Prostate Symptom Scores (IPSS) resolution was useful indicator regarding prolonged urination disorder after low dose rate prostate brachytherapy (LDR-PBT). However, there is variety of definitions for IPSS resolution and the interpretation is also various. So, we reexamined the definition of IPSS resolution considering QOL status. METHODS Between July 2004 and November 2017, 675 patients received LDR-PBT at our institution and were followed up at least 2 years. Prostate Specific Antigen (PSA), IPSS and QOL Scores were assessed pre-implant as well as at 1, 3, and 6 months after seed implantation, and every 6 months thereafter. IPSS resolution was defined as follows, definition 1: IPSS recovery to baseline score +0, definition 2: IPSS recovery to baseline score +1 and definition 3: IPSS recovery to baseline score +2. We also assessed correlation of IPSS resolution and QOL scores in accordance with each definition, and selected the most appropriate one. Using logistic-regression analyses, we also evaluated clinical factors with potential to delay IPSS resolution, which was most related to QOL Scores, including age, pretreatment IPSS, clinical stage, androgen deprivation therapy (ADT), prostate volume (PV), radiation dose to 90% of prostate volume (D90), and radiation dose to 30% of the urethral volume (UD30). RESULTS In definition 1, IPSS resolution rate recovered from 11.5% to 51.0% during a time period from 1 month to 36 months after seed implantation. In definition 2, IPSS resolution rate recovered from 16.0% to 58.1% during the same periods and in definition 3, IPSS resolution rate recovered from 22.0% to 66.0% (Table 1). In follow-up after seed implantation, it was definition 3 that QOL recovery adapted to IPSS resolution most closely (Table 2). In definition 3, baseline IPSS more than 8 points (p<0.001) and D90 more than 160 Gy (p<0.001) were significant predictors for delayed IPSS resolution on multivariate analysis. CONCLUSIONS Baseline IPSS+2 is the most appropriate definition of IPSS resolution which correlates most closely with QOL recovery after prostate brachytherapy. In this definition, higher baseline IPSS and higher D90 were predictors for prolonged urination disorder. © 2018FiguresReferencesRelatedDetails Volume 199Issue 4SApril 2018Page: e274 Advertisement Copyright & Permissions© 2018MetricsAuthor Information Hidehisa Mori More articles by this author Tomoharu Fukumori More articles by this author Kei Daizumoto More articles by this author Keisuke Ozaki More articles by this author Yoshito Kusuhara More articles by this author Tomoya Fukawa More articles by this author Yasuyo Yamamoto More articles by this author Kunihisa Yamaguchi More articles by this author Masayuki Takahashi More articles by this author Hiro-omi Kanayama More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...