MP22-03 COGNITIVE PERFORMANCE CORRELATES WITH BRAIN ACTIVATION IN WOMEN WITH URGENCY URINARY INCONTINENCE

Abstract

You have accessJournal of UrologyImaging/Radiology: Uroradiology II (MP22)1 Sep 2021MP22-03 COGNITIVE PERFORMANCE CORRELATES WITH BRAIN ACTIVATION IN WOMEN WITH URGENCY URINARY INCONTINENCE Rachel High, Zhaoyue Shi, Jill M. Danford, Erin T. Bird, Thomas J. Kuehl, Christof Karmonik, and Rose Khavari Rachel HighRachel High More articles by this author , Zhaoyue ShiZhaoyue Shi More articles by this author , Jill M. DanfordJill M. Danford More articles by this author , Erin T. BirdErin T. Bird More articles by this author , Thomas J. KuehlThomas J. Kuehl More articles by this author , Christof KarmonikChristof Karmonik More articles by this author , and Rose KhavariRose Khavari More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000002013.03AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: The prevalence of urgency urinary incontinence (UUI) and cognitive impairment increase with age. Some studies indicate UI may be an early symptom of ongoing neurodegeneration. Brain activation studies of healthy and cognitively impaired adults have found correlations between brain activation and cognitive performance. There are no studies to evaluate brain activation in women with UUI screened for cognitive impairment. This study examines whether clinical cognitive scores correlate with brain activation patterns in women with UUI not undergoing therapy. METHODS: This is an observational cohort study of functional MRI (fMRI) and cognitive and urinary clinical data from women with UUI and therapy naive. Women aged ≥50 years completed symptom questionnaires and a modified Auditory Verbal Learning test. Subjects with incomplete bladder emptying, moderate-severe depression or anxiety, screening assessment positive for cognitive impairment, and pelvic floor therapy or UUI medications within the last 6 months were excluded. Learning over trials (LOT), short term retention (STR), long term retention (LTR), recognition % correct (Rc%) scores which were scaled for age-correction were calculated. Data was transformed into MNI 152 space for whole brain voxel-wise analysis. A fMRI activation map was created from which areas of significant activation were identified (students t-test p<0.05). Correlation coefficients were calculated for the T-statistics of each region with cognitive scores. Significant (p<0.05) correlations were reported for each region & respective LOT, STR, LTR, and Rc% scores. RESULTS: Images were obtained in twelve women with a median (IQR) age of 64 (55,68) years. Bladder diaries showed median (IQR) daily: 10 (9,10) urgency episodes, 11 (9,12) voids, and 5 (3, 5) leaks with urgency. Activation of regions involved in memory encoding and retrieval, including the hippocampus, inversely correlated with multiple cognitive testing domains (Table). Activity in the insula, cingulate gyrus, and prefrontal cortex did not correlate with cognitive scores. CONCLUSIONS: In women with UUI, performance on learning, recall, and recognition tasks negatively correlates with activation in regions involved in episodic memory. Source of Funding: International Urogynecological Association Clinical Research Grant and Baylor Scott & White Health Department of Women's Health. Dr. Rose Khavari is partially supported by K23DK118209 through NIDDK © 2021 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 206Issue Supplement 3September 2021Page: e391-e391 Advertisement Copyright & Permissions© 2021 by American Urological Association Education and Research, Inc.MetricsAuthor Information Rachel High More articles by this author Zhaoyue Shi More articles by this author Jill M. Danford More articles by this author Erin T. Bird More articles by this author Thomas J. Kuehl More articles by this author Christof Karmonik More articles by this author Rose Khavari More articles by this author Expand All Advertisement Loading ...