MP22-13 FUNCTIONAL AND PSYCHOLOGICAL COMPARATIVE AND PROSPECTIVE ANALYSIS OF PATIENTS WITH PROSTATE CANCER SUBMITTED TO RADICAL PROSTATECTOMY, EXTERNAL RADIOTHERAPY OR ACTIVE SURVEILLANCE

Abstract

You have accessJournal of UrologyProstate Cancer: Localized: Radiation Therapy1 Apr 2018MP22-13 FUNCTIONAL AND PSYCHOLOGICAL COMPARATIVE AND PROSPECTIVE ANALYSIS OF PATIENTS WITH PROSTATE CANCER SUBMITTED TO RADICAL PROSTATECTOMY, EXTERNAL RADIOTHERAPY OR ACTIVE SURVEILLANCE Martina Maggi, Alessandro Sciarra, Alessandro Gentilucci, Stefano Salciccia, vincenzo Gentile, Daniela Musio, Vincenzo Tombolini, and Alessio Guandalini Martina MaggiMartina Maggi More articles by this author , Alessandro SciarraAlessandro Sciarra More articles by this author , Alessandro GentilucciAlessandro Gentilucci More articles by this author , Stefano SalcicciaStefano Salciccia More articles by this author , vincenzo Gentilevincenzo Gentile More articles by this author , Daniela MusioDaniela Musio More articles by this author , Vincenzo TomboliniVincenzo Tombolini More articles by this author , and Alessio GuandaliniAlessio Guandalini More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2018.02.724AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES To evaluate the functional and psychological impact of different primary treatments in patients with Prostate Cancer (PC) . We assessed different mental health measures over time using validated questionnaires in men who underwent Active Surveillance (AS), Radical Prostatectomy (RP) or External Radiotherapy (EBRT) (at 1-, 3-, 6-, 12-month interval after therapy). METHODS We conducted a single-centre prospective non randomized study. In total 220 patients with a diagnosis of PC, suitable for primary treatments, were included in the analysis. Inclusion criteria were: localized or locally advanced PC (T1-T3,N0,M0); primary treatment such as RP, EBRT or AS; no evidence of disease progression during the follow-up. Our evaluation was mainly based on self-administered and validated questionnaires on functional and psychological parameters. Urinary symptoms and incontinence were evaluated using the ICS male SF and the IPSS questionnaires. Erectile function was assessed using the International Index of Erectile Function-5 (IIEF-5). Health related QoL was evaluated using the SF-12 standard questionnaire and the UCLA-PC Index (urinary, bowel and sexual function). Anxiety, depression and PD were evaluated using HADS, PHQ-9 and PDI. The repeated measure analysis of variance (ANOVA) univariates and multivariates analysis were performed. RESULTS Some baseline socio-demographic characteristics of our population significantly (p <0,05) influenced results in terms of questionnaire scores in the post-treatment follow-up, whereas baseline clinical characteristics of the tumor were less associated. Functional aspects were differently influenced by the three treatments. In particular EBRT was associated with a significant (p <0,01) worsening in bowel function (UCLA-bowel at 1-month follow-up), whereas RP was associated with a significant (p <0,01) worsening in urinary (IPSS) and sexual (IIEF-5) functions. Regarding psychological function, EBRT was associated with a higher and significant (p< 0,01) worsesing in PD, anxiety and depression (HADS and PHQ-9), in particular at 1-month but also in the long-term follow-up. AS was associated with a significant (p< 0,01) increase of depression scores (HADS and PHQ-9) only at 12-month interval. RP was associated with the lowest variation in all PD questionnaires. At the multivariate analysis the choice of treatment was a significant factor influencing PD scores but it depended from functional results. CONCLUSIONS The different primary treatments indicated for PC are able to significantly influence PD, anxiety and depression of our patients during the follow-up, in particular EBRT showed a short-term whereas AS a long-term effect. This impact is more realated to the funcional modification due to treatments than to the treatment choice itself. © 2018FiguresReferencesRelatedDetails Volume 199Issue 4SApril 2018Page: e277 Advertisement Copyright & Permissions© 2018MetricsAuthor Information Martina Maggi More articles by this author Alessandro Sciarra More articles by this author Alessandro Gentilucci More articles by this author Stefano Salciccia More articles by this author vincenzo Gentile More articles by this author Daniela Musio More articles by this author Vincenzo Tombolini More articles by this author Alessio Guandalini More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...