MP21-12 PROPENSITY SCORE MATCHED ANALYSIS OF SINGLE FRACTION RADIOSURGERY VERSUS OPEN PARTIAL NEPHRECTOMY IN RENAL CELL CARCINOMA: ONCOLOGICAL OUTCOMES

Abstract

You have accessJournal of UrologyKidney Cancer: Localized: Surgical Therapy III (MP21)1 Apr 2020MP21-12 PROPENSITY SCORE MATCHED ANALYSIS OF SINGLE FRACTION RADIOSURGERY VERSUS OPEN PARTIAL NEPHRECTOMY IN RENAL CELL CARCINOMA: ONCOLOGICAL OUTCOMES Michael Staehler*, Christina Schuler, Anabel Graser, Severin Rodler, Alexander Tamaluans, Christoph Fuerweger, and Alexander Muacevic Michael Staehler*Michael Staehler* More articles by this author , Christina SchulerChristina Schuler More articles by this author , Anabel GraserAnabel Graser More articles by this author , Severin RodlerSeverin Rodler More articles by this author , Alexander TamaluansAlexander Tamaluans More articles by this author , Christoph FuerwegerChristoph Fuerweger More articles by this author , and Alexander MuacevicAlexander Muacevic More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000000854.012AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: High-dose local stereotactic radiosurgery (SRS) has been introduced as non-invasive alternative to surgery in renal masses. We compared patients with renal tumors who were treated with single-fraction SRS to patients who underwent open partial nephrectomy (OPN). METHODS: Out of n=571 consecutive patients undergoing OPN and n=99 patients who underwent SRS we could match n=35 with a propensity score between 01/2009 and 12/2017. Matching criteria were ECOG, age, clinical TNM and tumor diameter. Tumor response, renal function, survival, and adverse events were estimated every three months with a follow-up of at least six months. RESULTS: 35 patients were identified to be included in the propensity score matching analysis. Median age was 65 years for SRS (range 58-75) and 71 (range 56-76) for OPN (p=0.131) Median diameter of renal tumors was 2.8 cm (range 2.4-3.9) for SRS and 3.5 cm (2.8-4.5) for OPN, p=0.104. Median follow-up was 28.1 months (range 6.0- 78.3 months). Local tumor control nine months after SRS and OPN was 98% (95% CI: 89-99%). Renal function remained stable with a median creatinine clearance (CKD- EPI) at baseline of 76.8mlmin/1.73m2 (range 25.3-126.3) and 70.3ml/min/1.73m2 (range 18.6-127.3) at follow-up (p=0.89). Median overall survival was not reached. No difference in OS was seen in the SRS compared to OPN (p=0.459). No major complications have been encountered in both groups. CONCLUSIONS: Single-fraction SRS as an outpatient procedure is an alternative to OPN in selected patients. Oncological results are similar to those of OPN. Functional results are so far excellent. Further studies are needed to determine long-term results and limits of SRS in this setting. Source of Funding: None © 2020 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 203Issue Supplement 4April 2020Page: e322-e322 Advertisement Copyright & Permissions© 2020 by American Urological Association Education and Research, Inc.MetricsAuthor Information Michael Staehler* More articles by this author Christina Schuler More articles by this author Anabel Graser More articles by this author Severin Rodler More articles by this author Alexander Tamaluans More articles by this author Christoph Fuerweger More articles by this author Alexander Muacevic More articles by this author Expand All Advertisement PDF downloadLoading ...