MP20-08 PROSTATE CANCER LOCI WITH NEGATIVE MULTIPARAMETRIC MRI FOR PROSTATE CANCER: CORRELATION WITH PROSTATECTOMY SPECIMENS

Abstract

You have accessJournal of UrologyProstate Cancer: Staging I1 Apr 2017MP20-08 PROSTATE CANCER LOCI WITH NEGATIVE MULTIPARAMETRIC MRI FOR PROSTATE CANCER: CORRELATION WITH PROSTATECTOMY SPECIMENS Katsuhiro Ito, Takashi Kobayashi, Akihiro Furuta, Yuki Teramoto, Naoki Terada, Shusuke Akamatsu, Toshinari Yamasaki, Takahiro Inoue, and Osamu Ogawa Katsuhiro ItoKatsuhiro Ito More articles by this author , Takashi KobayashiTakashi Kobayashi More articles by this author , Akihiro FurutaAkihiro Furuta More articles by this author , Yuki TeramotoYuki Teramoto More articles by this author , Naoki TeradaNaoki Terada More articles by this author , Shusuke AkamatsuShusuke Akamatsu More articles by this author , Toshinari YamasakiToshinari Yamasaki More articles by this author , Takahiro InoueTakahiro Inoue More articles by this author , and Osamu OgawaOsamu Ogawa More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2017.02.640AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Precise localization of tumor locus is critically important for successful focal therapy in prostate cancer. The accuracy of multiparametric MRI (mpMRI) for prostate cancer localization is still unknown. METHODS We retrospectively analyzed 176 prostate cancer patients who underwent preoperative 3.0T multiparametric MRI (mpMRI) followed by radical prostatectomy (RP) without neoadjuvant androgen deprivation. Images of mpMRI was evaluated by a single radiologist based on PI-RADS version 2. PI-RADS score 4 or greater was considered positive. Tumor distribution was evaluated on radical prostatectomy specimen sliced at 5-mm thick and tumor volume was estimated based on planimetry. RESULTS Of the 176 study patients, 79 (45%) had negative mpMRI. Patients with negative mpMRI had smaller index tumor compared with those with positive mpMRI with a marginal significance (1.79 ± 0.25 vs 20.5 ± 0.22 cc., p = 0.05, Figure and Table). They were also more likely to have clinically insignificant cancer (Gleason score ≤6 and tumor volume <0.5 cc.) compared with those with positive mpMRI (Tables). However, the sensitivity and specificity for clinically significant prostate cancer was only 60% and 57%, respectively, indicating that mpMRI missed 40% of clinically significant cancer. CONCLUSIONS Although negative mpMRI is associated with favorable pathological findings in prostate cancer patients who underwent radical prostatectomy, mpMRI could not safely exclude clinically significant index tumor. Further improvement in the accuracy for tumor localization is warranted for the possible application of mpMRI to plan focal therapy. © 2017FiguresReferencesRelatedDetails Volume 197Issue 4SApril 2017Page: e242 Advertisement Copyright & Permissions© 2017MetricsAuthor Information Katsuhiro Ito More articles by this author Takashi Kobayashi More articles by this author Akihiro Furuta More articles by this author Yuki Teramoto More articles by this author Naoki Terada More articles by this author Shusuke Akamatsu More articles by this author Toshinari Yamasaki More articles by this author Takahiro Inoue More articles by this author Osamu Ogawa More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...