MP2-04 PROGNOSTIC VALUE OF SERUM CYFRA 21-1 IN PATIENTS WITH G3 OR MUSCLE INVASIVE UPPER URINARY TRACT CANCER

Abstract

You have accessJournal of UrologyBladder Cancer: Upper Tract TCC I1 Apr 2015MP2-04 PROGNOSTIC VALUE OF SERUM CYFRA 21-1 IN PATIENTS WITH G3 OR MUSCLE INVASIVE UPPER URINARY TRACT CANCER Akihiro Yano, Hironori Sugiyama, Eiken Cho, Hideki Takeshita, Yohei Okada, Hideki Nagamatsu, Makoto Morozumi, Satoru Kawakami, and Takumi Yamada Akihiro YanoAkihiro Yano More articles by this author , Hironori SugiyamaHironori Sugiyama More articles by this author , Eiken ChoEiken Cho More articles by this author , Hideki TakeshitaHideki Takeshita More articles by this author , Yohei OkadaYohei Okada More articles by this author , Hideki NagamatsuHideki Nagamatsu More articles by this author , Makoto MorozumiMakoto Morozumi More articles by this author , Satoru KawakamiSatoru Kawakami More articles by this author , and Takumi YamadaTakumi Yamada More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2015.02.127AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES No serum prognosticator has been established in patients with potentially lethal upper urinary tract cancer (UUTC). The aim of this study is to evaluate the prognostic value of serum CYFRA 21-1 (CYFRA) in these patients. METHODS Serum levels of CYFRA and C-reactive protein (CRP) were measured in 30 patients with G3 or muscle invasive UUTC between Jan 2012 and Aug 2014. Cut-off values of CYFRA and CRP were determined by receiver operating characteristic analyses. Prognostic values of age, stage, CYFRA and CRP were evaluated using multivariate analysis with a Cox proportional hazards model. RESULTS The median (range) values of CYFRA, and CRP were 4.1 (1.4–177.3) ng/mL and 0.2 (0–5.2) mg/dL, respectively. The median (range) age and follow-up period was 75 (64–86) years and 7.7 (1.1–29.9) months. Prognostic values of age (< 75 vs. ≥ 75), stage (non-metastatic vs. metastatic), CYFRA (cut-off 3.9 ng/mL) and CRP (cut-off 1.5 mg/dL) were evaluated dichotomously. Multivariate analyses revealed that p-values for age, stage and CRP is 0.83, 0.17, 0.48, respectively, and only CYFRA (P = 0.037) is a significant and an independent prognosticator. In 21 patients with metastatic disease (CYFRA cut-off 5.8 ng/mL), those with elevated CYFRA had 20.9-fold higher risk of cancer-specific mortality than those with non-elevated CYFRA. CONCLUSIONS The current results indicate that serum CYFRA level can be a prognosticator for patients with potentially lethal UUTC. Further prospective analyses will be needed to confirm our results. © 2015 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 193Issue 4SApril 2015Page: e11-e12 Advertisement Copyright & Permissions© 2015 by American Urological Association Education and Research, Inc.MetricsAuthor Information Akihiro Yano More articles by this author Hironori Sugiyama More articles by this author Eiken Cho More articles by this author Hideki Takeshita More articles by this author Yohei Okada More articles by this author Hideki Nagamatsu More articles by this author Makoto Morozumi More articles by this author Satoru Kawakami More articles by this author Takumi Yamada More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...