MP19-18 NOMOGRAM PREDICTING RENAL FUNCTION RECOVERY POST DIVERSION IN PATIENTS WITH OBSTRUCTIVE UROPATHY

Abstract

You have accessJournal of UrologyCME1 May 2022MP19-18 NOMOGRAM PREDICTING RENAL FUNCTION RECOVERY POST DIVERSION IN PATIENTS WITH OBSTRUCTIVE UROPATHY Gopal Sharma, Sudheer K. Devana, Ravimohan S. Mavuduru, and Kalpesh M. Parmar Gopal SharmaGopal Sharma More articles by this author , Sudheer K. DevanaSudheer K. Devana More articles by this author , Ravimohan S. MavuduruRavimohan S. Mavuduru More articles by this author , and Kalpesh M. ParmarKalpesh M. Parmar More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000002552.18AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Identifying the predictors of recovery of renal function following urinary diversion in patients with obstructive uropathy (OU) can be of great prognostic and clinical significance to a urologist. We aimed to develop a nomogram predicting recovery of renal function in patients with OU following urinary diversion. METHODS: In this prospective observational study, we included patients of OU (aged 18-65 years) presenting with raised serum creatinine (>2.0 mg/dl) due to various etiologies. Renal function recovery was defined as creatinine ≤1.5 at 4 weeks after diversion. Univariate and multivariate regression analysis was used to identify predictors of renal function recovery. Nomogram was developed using variables identified in multivariate analysis. Nomogram was internally validated with boot strapping, goodness of fit, calibration plot and receiver operating curve (ROC) analysis. Decision curve analysis (DCA) was used to determine clinical utility of the nomogram. RESULTS: Of 110 patients included in the study, 40 patients (36.4%) had renal function recovery after diversion. On multivariate analysis, age, etiology, duration of symptoms, baseline hemoglobin level and pH were identified as independent predictors of renal function recovery. Nomogram was developed using above mentioned variables, internally validated and had an area under curve of 0.89 for predicting renal recovery. Nomogram was found to be clinically useful at threshold probability of 5% renal recovery. CONCLUSIONS: We developed and internally validated a nomogram which is highly accurate and simple to use in predicting renal function recovery after diversion in patients with OU. However, it needs external validation before widespread use. Source of Funding: None © 2022 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 207Issue Supplement 5May 2022Page: e314 Advertisement Copyright & Permissions© 2022 by American Urological Association Education and Research, Inc.MetricsAuthor Information Gopal Sharma More articles by this author Sudheer K. Devana More articles by this author Ravimohan S. Mavuduru More articles by this author Kalpesh M. Parmar More articles by this author Expand All Advertisement PDF DownloadLoading ...