MP19-19 DIFFERENT PATHOLOGICAL TYPES OF ADULT PROSTATE SARCOMA WERE ASSOCIATED WITH DISTINCTIVE PROGNOSIS: EXPERIENCE OF A HIGH-VOLUME CENTER IN CHINA

Abstract

You have accessJournal of UrologyProstate Cancer: Localized: Surgical Therapy I (MP19)1 Apr 2020MP19-19 DIFFERENT PATHOLOGICAL TYPES OF ADULT PROSTATE SARCOMA WERE ASSOCIATED WITH DISTINCTIVE PROGNOSIS: EXPERIENCE OF A HIGH-VOLUME CENTER IN CHINA Rui Chen*, Hanxiao Wu, Yue Yang, Zhongyuan Yu, New York, NJ, Xiang Li, Weixiao Yang, Zijian Song, Na Ta, Huan Han, Lulu Deng, Shancheng Ren, Xu Gao, Yongwei Yu, and Yinghao Sun Rui Chen*Rui Chen* More articles by this author , Hanxiao WuHanxiao Wu More articles by this author , Yue YangYue Yang More articles by this author , Zhongyuan YuZhongyuan Yu More articles by this author , New York, NJNew York, NJ More articles by this author , Xiang LiXiang Li More articles by this author , Weixiao YangWeixiao Yang More articles by this author , Zijian SongZijian Song More articles by this author , Na TaNa Ta More articles by this author , Huan HanHuan Han More articles by this author , Lulu DengLulu Deng More articles by this author , Shancheng RenShancheng Ren More articles by this author , Xu GaoXu Gao More articles by this author , Yongwei YuYongwei Yu More articles by this author , and Yinghao SunYinghao Sun More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000000852.019AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Prostate sarcoma is a rare malignancy with a series of different pathological types. The prognosis of prostate sarcoma patients was not fully understood due to its rareness. We reported the survival and characteristics of prostate sarcoma treated at a single high-volume institution. METHODS: The medical records of 39 adult patients from January 2000 to March 2017 with a diagnosis of primary prostate sarcoma were retrieved. Univariate and multivariable Cox regression analysis were applied to identify the predictors of overall survival (OS), progression-free survival (PFS) and metastasis-free survival (MFS). RESULTS: The median OS was 15.2 months (range 2.3-171.8), and the OS rate at 1, 3 and 5 years was 69.2%, 23.1% and 10.3%, respectively. Patients were divided into 4 pathology types based on the prognosis (stromal sarcoma, undifferentiated pleomorphic sarcoma and others rare sarcomas; rhabdomyosarcoma; leiomyosarcoma; carcinosarcoma and gastrointestinal stromal tumor (GIST)). The most common histological type was rhabdomyosarcoma (10 cases, 25.6%). Multivariable Cox regression reveled that invasive disease at diagnosis (yes vs no, hazard ratio (HR) 5.69, p = 0.019), pathological type and adjuvant therapy (yes vs no, HR 0.30, p = 0.069) was associated with OS. Pathological type was associated with PFS (carcinosarcoma and GIST vs stromal sarcoma, HR 0.09, p = 0.011), and adjuvant therapy (yes vs no HR 8.66, p = 0.098) was associated with MFS. CONCLUSIONS: Different pathological types of prostate sarcoma were associated with distinctive prognosis. Patients with carcinosarcoma and GIST of prostate had the longer OS, followed by leiomyosarcoma, rhabdomyosarcoma and stromal sarcoma and others. Pathological type like leiomyosarcoma, carcinosarcoma and GIST, no invasive disease and the application of adjuvant therapy were associated with overall long-term survival. The application of adjuvant therapy may improve the overall survival of these patients. Further studies are needed to identify better treatment strategies for prostate sarcoma especially in the age of precision medicine. Source of Funding: Chinese National Natural Science Foundation Youth Project (81702514) © 2020 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 203Issue Supplement 4April 2020Page: e306-e306 Advertisement Copyright & Permissions© 2020 by American Urological Association Education and Research, Inc.MetricsAuthor Information Rui Chen* More articles by this author Hanxiao Wu More articles by this author Yue Yang More articles by this author Zhongyuan Yu More articles by this author New York, NJ More articles by this author Xiang Li More articles by this author Weixiao Yang More articles by this author Zijian Song More articles by this author Na Ta More articles by this author Huan Han More articles by this author Lulu Deng More articles by this author Shancheng Ren More articles by this author Xu Gao More articles by this author Yongwei Yu More articles by this author Yinghao Sun More articles by this author Expand All Advertisement PDF downloadLoading ...