MP18-03 PHENOTYPING PATIENTS WITH POLYURIA

Abstract

You have accessJournal of UrologyCME1 May 2022MP18-03 PHENOTYPING PATIENTS WITH POLYURIA George Fisch, Alexander Fang, Connelly Miller, Claire Choi, Thomas Monaghan, Edward Smith, Learta Prishtina, Jeffrey Weiss, and Jerry Blaivas George FischGeorge Fisch More articles by this author , Alexander FangAlexander Fang More articles by this author , Connelly MillerConnelly Miller More articles by this author , Claire ChoiClaire Choi More articles by this author , Thomas MonaghanThomas Monaghan More articles by this author , Edward SmithEdward Smith More articles by this author , Learta PrishtinaLearta Prishtina More articles by this author , Jeffrey WeissJeffrey Weiss More articles by this author , and Jerry BlaivasJerry Blaivas More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000002551.03AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Patients with lower urinary tract symptoms (LUTS) may be subcategorized based on urinary output into polyuria, normal or oliguria groups as demonstrated by Blaivas et al (Can J Urol. 2021 Jun) and Clemens et al (Neurourol Urodyn., 2020 Apr). Polyuria may be caused by several pathologic conditions including diabetes mellitus (DM), chronic kidney disease (CKD), diabetes insipidus (DI), or primary polydipsia (PPD). While fluid restriction is appropriate for the majority of patients, doing so in all may result in serious complications. This study investigates the prevalence of these pathologic conditions in LUTS patients with polyuria. METHODS: Two lower urinary tract databases were retrospectively queried to identify men and women presenting with LUTS who filled out the validated Lower Urinary Tract Symptom Score (LUTSS) questionnaire (Blaivas et al, Can J Urol 2015 Oct), a 24-hour bladder diary on a mobile app* or on paper, and met criteria for polyuria (>2.5 L/day). Patients were divided into four groups: poorly controlled DM, DI, CKD grade 3, and PPD. A one-way ANOVA was performed to compare groups and Pearson correlation was run examining the relationship between LUTSS and bother with 24 HVV, MVV and total voids. *weShare® by Symptelligence Medical Informatics.com. RESULTS: Among 814 total patients presenting with a chief complaint of LUTS, 146 (18%) men and women completed 24 HBD and LUTSS questionnaires and met criteria for polyuria. 7.8% had poorly-controlled DM, 3.1% had DI, 4.7% had CKD grade 3 and 84.4% had PPD. Amongst groups, statistically significant differences were seen in measurements of 24 HVV, NUV, MVV, Daytime Voids, NPi, and Ni. A statistically significant relationship was seen between LUTSS and bother score, LUTSS and total voids, and bother and total voids. CONCLUSIONS: 18% of the patients with LUTS in this series were found to have polyuria based on a 24HBD. Within this cohort, four sub-populations were phenotyped demonstrating significant differences in 24HVV, NUV, MVV, daytime voids, NPi and Ni. Identifying the underlying etiology of polyuria should be carried out to safely treat patients with LUTS. Source of Funding: Institute for Bladder and Prostate Research © 2022 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 207Issue Supplement 5May 2022Page: e296 Advertisement Copyright & Permissions© 2022 by American Urological Association Education and Research, Inc.MetricsAuthor Information George Fisch More articles by this author Alexander Fang More articles by this author Connelly Miller More articles by this author Claire Choi More articles by this author Thomas Monaghan More articles by this author Edward Smith More articles by this author Learta Prishtina More articles by this author Jeffrey Weiss More articles by this author Jerry Blaivas More articles by this author Expand All Advertisement PDF DownloadLoading ...