MP17-13 MULTIPARAMETRIC MAGNETIC RESONANCE IMAGING AND MRI/ULTRASOUND FUSION-GUIDED BIOPSY PREDICTS TOTAL TUMOR BURDEN CONFIRMED BY WHOLE MOUNT PROSTATECTOMY

Abstract

You have accessJournal of UrologyImaging/Radiology: Uroradiology III1 Apr 2015MP17-13 MULTIPARAMETRIC MAGNETIC RESONANCE IMAGING AND MRI/ULTRASOUND FUSION-GUIDED BIOPSY PREDICTS TOTAL TUMOR BURDEN CONFIRMED BY WHOLE MOUNT PROSTATECTOMY Richard Ho, Arvin K. George, Thomas Frye, Steven Abboud, Raju Chelluri, Michele Fascelli, Chinonyerem Okoro, Nabeel Shakir, M. Minhaj Siddiqui, Vanessa Moreno, Annerleim Walton-Diaz, Sandeep Sankineni, Maria Merino, Baris Turkbey, Peter Choyke, Bradford J. Wood, and Peter Pinto Richard HoRichard Ho More articles by this author , Arvin K. GeorgeArvin K. George More articles by this author , Thomas FryeThomas Frye More articles by this author , Steven AbboudSteven Abboud More articles by this author , Raju ChelluriRaju Chelluri More articles by this author , Michele FascelliMichele Fascelli More articles by this author , Chinonyerem OkoroChinonyerem Okoro More articles by this author , Nabeel ShakirNabeel Shakir More articles by this author , M. Minhaj SiddiquiM. Minhaj Siddiqui More articles by this author , Vanessa MorenoVanessa Moreno More articles by this author , Annerleim Walton-DiazAnnerleim Walton-Diaz More articles by this author , Sandeep SankineniSandeep Sankineni More articles by this author , Maria MerinoMaria Merino More articles by this author , Baris TurkbeyBaris Turkbey More articles by this author , Peter ChoykePeter Choyke More articles by this author , Bradford J. WoodBradford J. Wood More articles by this author , and Peter PintoPeter Pinto More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2015.02.855AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Advances in multiparametric prostate magnetic resonance imaging (MP-MRI) coupled with targeted magnetic resonance imaging/ultrasound guided fusion biopsies (TBx) have allowed for better visualization and assessment of tumor characteristics. Tumor volume (TV) has been shown to be an important prognostic factor after radical prostatectomy (RP). We aim to assess whether imaging or biopsy parameters could predict total tumor burden determined on whole mount prostatectomy. METHODS Patients who underwent MP-MRI, TBx, and robotic assisted RP between 2007 and 2013 were reviewed. Lesions suspicious for prostate cancer (PCa) on MRI were manually segmented and TV calculated using iCAD software. Only TBx positive lesions were considered in calculating total MRI TV (MRTV). Pathology was reviewed by a single genitourinary pathologist and histopathological tumor volumes (HTV) were calculated using the ellipsoid formula (length × width × height × 0.52) in cm3, correcting for post-RP tissue shrinkage with a scaling factor of 1.15. Linear regression Pearson coefficients were computed to assess correlations. RESULTS We identified 177 patients who underwent MP-MRI, TBx/12-core biopsy, and subsequent RP, of which 46 patients had MRTV and HTV quantified. Mean PSA was 9.5 ng/ml with a mean age of 62.3 years. Total MRTV correlated with total HTV (R=0.44, p=0.002) (Figure 1). When examining index lesion MRTV, the correlation increased (R=0.44 to R=0.49) between MRTV and total HTV (p<0.001). As expected, index lesion MRTV also had a very strong correlation to index lesion HTV (R=0.61, p<0.001). Age, PSA, and TBx parameters (highest percent core and highest tumor core length) were not significant predictors of total HTV (Figure 1). CONCLUSIONS MRI parameters including total MRTV and index lesion MRTV correlated best with total gland tumor burden on whole mount pathology. Age, PSA, and traditional biopsy parameters such as percent core and tumor length failed to provide a strong correlation with HTV. MRI parameters coupled with TBx may be useful as a surrogate for estimating whole gland disease burden. © 2015 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 193Issue 4SApril 2015Page: e180-e181 Advertisement Copyright & Permissions© 2015 by American Urological Association Education and Research, Inc.MetricsAuthor Information Richard Ho More articles by this author Arvin K. George More articles by this author Thomas Frye More articles by this author Steven Abboud More articles by this author Raju Chelluri More articles by this author Michele Fascelli More articles by this author Chinonyerem Okoro More articles by this author Nabeel Shakir More articles by this author M. Minhaj Siddiqui More articles by this author Vanessa Moreno More articles by this author Annerleim Walton-Diaz More articles by this author Sandeep Sankineni More articles by this author Maria Merino More articles by this author Baris Turkbey More articles by this author Peter Choyke More articles by this author Bradford J. Wood More articles by this author Peter Pinto More articles by this author Expand All Advertisement Advertisement PDF DownloadLoading ...