MP17-12 IMMUNE SCORE OF TUMOR-INFILTRATING CD8+ AND FOXP3+ LYMPHOCYTES AS A NOVEL PROGNOSTIC BIOMARKER IN HIGH-RISK LOCALIZED PROSTATE CANCER WHO UNDERWENT RADICAL PROSTATECTOMY

Abstract

You have accessJournal of UrologyCME1 Apr 2023MP17-12 IMMUNE SCORE OF TUMOR-INFILTRATING CD8+ AND FOXP3+ LYMPHOCYTES AS A NOVEL PROGNOSTIC BIOMARKER IN HIGH-RISK LOCALIZED PROSTATE CANCER WHO UNDERWENT RADICAL PROSTATECTOMY Hiromi Sato, Shintaro Narita, Yoshiko Takahashi, Masanori Ishida, Mizuki Kobayashi, Soki Kasima, Ryohei Yamamoto, Taketoshi Nara, Mingguo Huang, Kazuyuki Numakura, Mitsuru Saito, Hiroshi Nanjo, and Tomonori Habuchi Hiromi SatoHiromi Sato More articles by this author , Shintaro NaritaShintaro Narita More articles by this author , Yoshiko TakahashiYoshiko Takahashi More articles by this author , Masanori IshidaMasanori Ishida More articles by this author , Mizuki KobayashiMizuki Kobayashi More articles by this author , Soki KasimaSoki Kasima More articles by this author , Ryohei YamamotoRyohei Yamamoto More articles by this author , Taketoshi NaraTaketoshi Nara More articles by this author , Mingguo HuangMingguo Huang More articles by this author , Kazuyuki NumakuraKazuyuki Numakura More articles by this author , Mitsuru SaitoMitsuru Saito More articles by this author , Hiroshi NanjoHiroshi Nanjo More articles by this author , and Tomonori HabuchiTomonori Habuchi More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000003237.12AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: For several cancer patients, immunotherapy has resulted in better outcomes, and tumor-infiltrating lymphocytes (TILs) have promising potential to be associated with prognosis of cancer. However, the clinical significance of TILs in high-risk localized prostate cancer (HRLPCa) is largely unknown. Here we investigate the effect of tissue-resident T cells on clinical outcomes in patients with HRLPCa who had a radical prostatectomy (RP). METHODS: Tumor microarrays were built using prostatectomy specimens from 240 cores of 80 HRLPCa treated with RP. Each specimen was scored individually using immunohistochemistry for the mean numbers of the CD3+, CD4+, CD8+, and FoxP3+ TILs (IHC). After being classified into high- and low-infiltration groups for each TILs, the association between the immune scores, clinicopathological characteristics, and biochemical recurrence-free survival (bRFS) was statistically evaluated. RESULTS: Patients in the higher infiltrate groups for CD3+, CD4+, CD8+, and FoxP3+ TILs had significantly lower PSA levels than those in the lower infiltrate groups, and the rate of pathological T3–4 disease was significantly higher in the low CD4+ group than in the CD4+ high group (p=0.015). No significant difference in bRFS was observed between the low and high groups of each TILs. The FoxP3 high+CD8 low group had significantly worse bRFS than the other groups (2-year bRFS: 88.5% vs. 60.0%, p=0.004) after the groups were divided into four groups, including FoxP3 low +CD8 low, FoxP3 low+CD8 high, FoxP3 high+CD8 low, and FoxP3 high+CD8 high. In contrast, the combination of CD4 and FoxP3 scores was not statistically related to bPFS (p=0.228). FoxP3 high+CD8 low was found to be an independent predictor of bRFS outcome in the multivariate analysis (hazard ratio: 3.431; 95% CI: 1.048–11.240; p=0.049); as well as pathological T3–4 diseases (hazard ratio: 3.546; 95% CI: 1.250–10.060; p=0.017). CONCLUSIONS: The combined IHC scores with CD8 and FoxP3 in RP specimens may be a potential biomarker for biochemical recurrence in patients with HRLPCa. Source of Funding: GlaxoSmithKline plc © 2023 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 209Issue Supplement 4April 2023Page: e217 Advertisement Copyright & Permissions© 2023 by American Urological Association Education and Research, Inc.MetricsAuthor Information Hiromi Sato More articles by this author Shintaro Narita More articles by this author Yoshiko Takahashi More articles by this author Masanori Ishida More articles by this author Mizuki Kobayashi More articles by this author Soki Kasima More articles by this author Ryohei Yamamoto More articles by this author Taketoshi Nara More articles by this author Mingguo Huang More articles by this author Kazuyuki Numakura More articles by this author Mitsuru Saito More articles by this author Hiroshi Nanjo More articles by this author Tomonori Habuchi More articles by this author Expand All Advertisement PDF downloadLoading ...