MP16-12 CORRELATION OF PROSTATIC HISTOLOGICAL INFLAMMATION CHARACTERIZED BY TYPE AND SITE WITH PROSTATE SPECIFIC ANTIGEN VALUES IN MEN WITH BENIGN FINDINGS ON PROSTATE BIOPSY

Abstract

You have accessJournal of UrologyInfections/Inflammation of the Genitourinary Tract: Prostate & Genitalia1 Apr 2014MP16-12 CORRELATION OF PROSTATIC HISTOLOGICAL INFLAMMATION CHARACTERIZED BY TYPE AND SITE WITH PROSTATE SPECIFIC ANTIGEN VALUES IN MEN WITH BENIGN FINDINGS ON PROSTATE BIOPSY Michelle Edwards, Apostolos Dimitromanolakis, Susan Lau, Bassel Bachir, Eleftherios Diamandis, Brendan Mullen, and Keith Jarvi Michelle EdwardsMichelle Edwards More articles by this author , Apostolos DimitromanolakisApostolos Dimitromanolakis More articles by this author , Susan LauSusan Lau More articles by this author , Bassel BachirBassel Bachir More articles by this author , Eleftherios DiamandisEleftherios Diamandis More articles by this author , Brendan MullenBrendan Mullen More articles by this author , and Keith JarviKeith Jarvi More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2014.02.585AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Histological inflammation is a common finding in prostate biopsies. We attempted to investigate how inflammation characterized by type and site is related to prostate specific antigen (PSA) concentration, prostate specific antigen density (PSAD) and prostate specific antigen velocity (PSAV) in men with benign findings on prostate biopsy. METHODS 162 patients underwent transrectal ultrasound guided prostate biopsy due to an elevated PSA and/or an abnormal finding on a digital rectal examination. Benign biopsies (negative for prostate cancer, ASAP, and PIN) were included in this study (n=59). Histological inflammation of each biopsy core was categorized according to each combination of type (acute, chronic) and site (glandular, periglandular, stromal), and each category graded for extent based on a four point scale developed by Nickel and colleagues [1]. The overall inflammation score (%) for each category was calculated by totalling the score of each core from a biopsy and dividing by the maximum possible score. The maximum inflammation score for each category was the highest grade of any core from a biopsy. Correlation between inflammation scores and total PSA, PSAD, and PSAV were assessed with Spearman’s rank correlations. RESULTS Analysis revealed three statistically significant relationships. (1) Maximum chronic stromal inflammation score showed a significant inverse relationship with PSAD and PSAV values (rho=-0.36, p=0.005 and rho=-0.45, p=0.01, respectively). (2) Acute glandular inflammation score as well as maximum acute glandular inflammation score showed a significant correlation with total PSA levels (rho=0.44, p=0.0005 and rho=0.39, p=0.002, respectively). (3) Chronic stromal inflammation score showed a significant correlation with both patient age (rho=0.43, p=0.0006) and prostate volume (rho=0.45, p=0.0003). Chronic periglandular inflammation score also showed a significant correlation with prostate volume (rho=0.40, p=0.002). CONCLUSIONS Categorizing and grading inflammation by type and site allowed us to better deduce the effects of histological inflammation on PSA values. A focus of chronic stromal inflammation showed a protective effect on PSAD and PSAV. Acute glandular inflammation showed a contributing effect to elevated PSA values. These trends may be useful in evaluating benign biopsy results in order to determine the necessity of repeat biopsies. [1] Nickel JC et al, Journal of Urology, Sept 2007. © 2014FiguresReferencesRelatedDetails Volume 191Issue 4SApril 2014Page: e157 Advertisement Copyright & Permissions© 2014MetricsAuthor Information Michelle Edwards More articles by this author Apostolos Dimitromanolakis More articles by this author Susan Lau More articles by this author Bassel Bachir More articles by this author Eleftherios Diamandis More articles by this author Brendan Mullen More articles by this author Keith Jarvi More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...