MP15-07 HEALTH-RELATED QUALITY OF LIFE FOR MEN WITH LOW RISK PROSTATE CANCER MANAGED WITH ACTIVE SURVEILLANCE COMPARED TO A CANCER-SCREENING COHORT WITHOUT PROSTATE CANCER

Abstract

You have accessJournal of UrologyGeneral & Epidemiological Trends & Socioeconomics: Quality of Life1 Apr 2014MP15-07 HEALTH-RELATED QUALITY OF LIFE FOR MEN WITH LOW RISK PROSTATE CANCER MANAGED WITH ACTIVE SURVEILLANCE COMPARED TO A CANCER-SCREENING COHORT WITHOUT PROSTATE CANCER Khanh Pham, Claudio Jeldres, Richard Johnston, Jennifer Cullen, Katherine Odem-Davis, Erika Wolff, Katherine Levie, Lauren Hurwitz, and Christopher Porter Khanh PhamKhanh Pham More articles by this author , Claudio JeldresClaudio Jeldres More articles by this author , Richard JohnstonRichard Johnston More articles by this author , Jennifer CullenJennifer Cullen More articles by this author , Katherine Odem-DavisKatherine Odem-Davis More articles by this author , Erika WolffErika Wolff More articles by this author , Katherine LevieKatherine Levie More articles by this author , Lauren HurwitzLauren Hurwitz More articles by this author , and Christopher PorterChristopher Porter More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2014.02.560AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Active surveillance (AS) is an important alternative to definitive therapy for men with low risk prostate cancer (PCa). Accurate information regarding the health-related quality of life (HRQoL) side effects for each treatment modality is critical for patient decision making. AS involves repeat prostate needle biopsies (PNB), which may cause sexual and/or urinary side effects. To evaluate HRQoL of patients managed with AS we prospectivley studied the HRQoL in 2 populations: AS patients and a cancer-screening cohort without PCa. Our aim was to specifically assess the HRQoL impact of AS when compared to a control group of men that had undergone negative PNB. METHODS A prospective cohort study was performed on patients enrolled into the Center for Prostate Disease Research (CPDR) multi-center national database during 2007–2012. All patients were counseled for treatment options in a multi-disciplinary clinic where all options were discussed. HRQoL was assessed at the time of primary evaluation, at PNB for possible PCa and then at fixed time intervals using two standardized instruments: Medical Outcomes Study Short Form 36 (SF-36) and Expanded Prostate Cancer Index Composite (EPIC). Change scores in SF-36 and EPIC subscales at 12 and 24 months after baseline were compared for patients who had two or more negative prostate biopsies (PNB Neg) to patients with NCCN guideline low risk PCa managed with AS. Student’s t-test was used for statistical analysis. RESULTS The study included 223 PNB-Neg patients (68.4%) median age 62.6 years, and 103 AS patients (31.6%) median age 67.1 years. EPIC and SF-36 subscale change scores are presented in Table 1. AS patients demonstrated statistically significant declines in sexual function at 1 and 2 years and urinary function at 2 years when compared to PNB Neg patients. Importantly, there were no HRQoL differences in bowel function, physical health or mental health between the 2 groups. CONCLUSIONS Our analysis of prospectivley collected HRQoL data indicates that men managed with AS have worse sexual and urinary function compared to men without PCa that have undergone negative PNB. These findings should facilitate medical decision-making in men considering AS, and allow for more realistic expectations regarding outcomes. © 2014FiguresReferencesRelatedDetails Volume 191Issue 4SApril 2014Page: e147 Advertisement Copyright & Permissions© 2014MetricsAuthor Information Khanh Pham More articles by this author Claudio Jeldres More articles by this author Richard Johnston More articles by this author Jennifer Cullen More articles by this author Katherine Odem-Davis More articles by this author Erika Wolff More articles by this author Katherine Levie More articles by this author Lauren Hurwitz More articles by this author Christopher Porter More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...