MP15-02 SEMEN REACTIVE OXYGEN SPECIES LEVELS IN PATIENTS WITH CHRONIC PROSTATITIS/CHRONIC PELVIC PAIN SYNDROME CATEGORY IIIA: RELATIONSHIP WITH THE NATIONAL INSTITUTES OF HEALTH-CHRONIC PROSTATITIS SYMPTOM INDEX

Abstract

You have accessJournal of UrologyInfections/Inflammation/Cystic Disease of the Genitourinary Tract: Prostate & Genitalia I1 Apr 2018MP15-02 SEMEN REACTIVE OXYGEN SPECIES LEVELS IN PATIENTS WITH CHRONIC PROSTATITIS/CHRONIC PELVIC PAIN SYNDROME CATEGORY IIIA: RELATIONSHIP WITH THE NATIONAL INSTITUTES OF HEALTH-CHRONIC PROSTATITIS SYMPTOM INDEX Ilter Alkan, Meral Yüksel, Anil Atalay, Lütfi Canat, çigdem Arabaci, Muammer Bozkurt, and Murad Basar Ilter AlkanIlter Alkan More articles by this author , Meral YükselMeral Yüksel More articles by this author , Anil AtalayAnil Atalay More articles by this author , Lütfi CanatLütfi Canat More articles by this author , çigdem Arabaciçigdem Arabaci More articles by this author , Muammer BozkurtMuammer Bozkurt More articles by this author , and Murad BasarMurad Basar More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2018.02.515AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES The etiology of CP/CPPS is still unclear despite many studies suggests the possible role of infectious, inflammatory, immunologic and neuronal causes. Reactive oxygen species (ROS) induced oxidative stress (OS) could be an etiologic factor in CP/CPPS. We would like to determine if there is any difference between seminal ROS levels in patients with CP/CPPS National Institutes of Health (NIH) category IIIA and age-matched healthy men and also determine any positive relationship between seminal ROS levels and disease symptom severity scored by The Turkish version of NIH-Chronic Prostatitis Symptom Index (NIH-CPSI). METHODS We prospectively evaluated 63 patients for prostatitis-like symptoms. Thirty-three patients (age, mean ± SD; 41.1 ± 9.75) provided study inclusion criteria for CP/CPPS category IIIA and enrolled into the study. Eight age-matched (age: 40.7 ± 1.98) healthy men consist control group. The Turkish version of NIH-CPSI form was completed by the study participants. Semen characteristics were examined according to the WHO 2010 criteria. No patients had leukocytospermia (≥ 1.0 x106 white blood cells/mL). Swim-up method was used for the sperm preparation. ROS levels were measured by chemiluminescence method via luminol enhancer. Results are given as relative light unit (rlu) /106 spermatozoa /mL. The log of (ROS+1) was used in calculations. RESULTS The mean sperm concentrations (106/mL) and motilities (%) of patient group and control subjects were 121 ± 116 x 106/mL, 35.9 ± 9.94 % vs. 110.8 ± 77.37 x 106/mL, 39.6 ± 7.19 %, respectively. No statistically significant differences were found in age, semen sperm concentrations and motility in between CP/CPPS patients and the control subjects. (p = 0.903, 0.755 and 0.2001, respectively) CP/CPPS patients had higher luminol enhanced ROS levels 2.9 ± 0.45 than healthy control subjects 2.5 ± 0.20 (Mann-Whitney test, p = 0.002). We found that there was a moderately positive correlation between ROS levels and NIH-CPSI scores.(Spearman Correlation Test, r = 0.291, p=0.048) CONCLUSIONS Semen ROS levels in CP/CPPS category IIIA patients were significantly higher than healthy control subjects. Overproduction of ROS or OS could be an etiologic factor in this group of patients. Semen ROS levels were positively correlated with NIH-CPSI scores, it could be another tool for assessing disease severity in CP/CPPS category IIIA patients. © 2018FiguresReferencesRelatedDetails Volume 199Issue 4SApril 2018Page: e189 Advertisement Copyright & Permissions© 2018MetricsAuthor Information Ilter Alkan More articles by this author Meral Yüksel More articles by this author Anil Atalay More articles by this author Lütfi Canat More articles by this author çigdem Arabaci More articles by this author Muammer Bozkurt More articles by this author Murad Basar More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...