MP14-17 INCREASED RISK OF BIOCHEMICAL FAILURE AFTER RADICAL PROSTATECTOMY AMONG AFRICAN AMERICAN MEN WITH HIGH RISK PROSTATE CANCER

Abstract

You have accessJournal of UrologyProstate Cancer: Epidemiology & Natural History II1 Apr 2017MP14-17 INCREASED RISK OF BIOCHEMICAL FAILURE AFTER RADICAL PROSTATECTOMY AMONG AFRICAN AMERICAN MEN WITH HIGH RISK PROSTATE CANCER Yaw Nyame, Jeffrey Tosoian, Lamont Wilkins, Ridwan Alam, Kasra Yousefi, Meera Chappidi, Chandana Reddy, Elizabeth Humphreys, Debasish Sundi, Brian Chapin, Andrew J. Stephenson, Eric Klein, and Ashley Ross Yaw NyameYaw Nyame More articles by this author , Jeffrey TosoianJeffrey Tosoian More articles by this author , Lamont WilkinsLamont Wilkins More articles by this author , Ridwan AlamRidwan Alam More articles by this author , Kasra YousefiKasra Yousefi More articles by this author , Meera ChappidiMeera Chappidi More articles by this author , Chandana ReddyChandana Reddy More articles by this author , Elizabeth HumphreysElizabeth Humphreys More articles by this author , Debasish SundiDebasish Sundi More articles by this author , Brian ChapinBrian Chapin More articles by this author , Andrew J. StephensonAndrew J. Stephenson More articles by this author , Eric KleinEric Klein More articles by this author , and Ashley RossAshley Ross More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2017.02.481AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES African American men demonstrate significant disparities in prostate cancer outcomes compared to men of other ethnicities. This study aims to assess the difference in biochemical recurrence between African American men and non-African American men with high risk prostate cancer treated by radical prostatectomy. METHODS This is a multi-institutional observational study comprised of 1869 men with NCCN high risk prostate cancer managed primarily by radical prostatectomy at the Cleveland Clinic, Johns Hopkins University, and MD Anderson Cancer Center. In total, 233 (12.5%) men in this cohort self-identified as AA. A Cox regression model was constructed to predict the risk of biochemical recurrence (BCR) while adjusting for differences in clinical covariates between African American and non-African American men. All data is presented as median[IQR]. RESULTS On univariate analysis, African American men demonstrated differences in median age (60.0 years [54.0-65.0] vs. 57.0 years [52.0-67.0]), initial prostate specific antigen (PSA) (8.8 ng/ml [5.2-21.5] vs. 7.1 ng/ml [4.9-13.4]), number of cores with Gleason score 8 or greater disease (1[0-3] vs. 2[1-4]), T stage (1[1-2] vs. 2[1-2]), and grade group (4[4-5] vs. 4[4-5]), compared to non-African American men (all p < 0.01). African American men in the cohort had median follow-up of 36.5 months [14.3-59.5] compared to 36.2 months [14.1-62.0] among non-African American men (p = 0.81). Overall, the BCR-free probability was 54.7% and 51.2% for African American men and 61.3% and 51.4% for non-African American men at 3- and 5- years, respectively. On Cox regression, African American ethnicity was associated with hazard ratio 1.31 (95% CI 1.05, 1.63, p = 0.02) in a model controlling for age, initial PSA, clinical stage, grade group, and number of biopsy cores with Gleason 8 or higher disease. CONCLUSIONS African American ethnicity was associated with a 31% increased risk of biochemical recurrence when adjusted comparisons were performed. Further research is needed to determine if these observed differences in the rate of BCR are modifiable among AA men with high risk disease. © 2017FiguresReferencesRelatedDetails Volume 197Issue 4SApril 2017Page: e168 Advertisement Copyright & Permissions© 2017MetricsAuthor Information Yaw Nyame More articles by this author Jeffrey Tosoian More articles by this author Lamont Wilkins More articles by this author Ridwan Alam More articles by this author Kasra Yousefi More articles by this author Meera Chappidi More articles by this author Chandana Reddy More articles by this author Elizabeth Humphreys More articles by this author Debasish Sundi More articles by this author Brian Chapin More articles by this author Andrew J. Stephenson More articles by this author Eric Klein More articles by this author Ashley Ross More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...