MP13-18 IMPACTS OF APOLIPOPROTEIN A-1 AND ALPHA-FETOPROTEIN ON THE DEVELOPMENT OF BENIGN PROSTATIC HYPERPLASIA AND LOWER URINARY TRACT SYMPTOMS: RESULTS FROM A HIGH-VOLUME HEALTH CHECK-UP DATABASE

Abstract

You have accessJournal of UrologyBenign Prostatic Hyperplasia: Epidemiology & Evaluation1 Apr 2017MP13-18 IMPACTS OF APOLIPOPROTEIN A-1 AND ALPHA-FETOPROTEIN ON THE DEVELOPMENT OF BENIGN PROSTATIC HYPERPLASIA AND LOWER URINARY TRACT SYMPTOMS: RESULTS FROM A HIGH-VOLUME HEALTH CHECK-UP DATABASE Kwang Suk Lee, Kyo Chul Koo, Do Kyung Kim, Jongsoo Lee, Jong Won Kim, Jae Yong Jeong, Sung Ku Kang, and Byung Ha Chung Kwang Suk LeeKwang Suk Lee More articles by this author , Kyo Chul KooKyo Chul Koo More articles by this author , Do Kyung KimDo Kyung Kim More articles by this author , Jongsoo LeeJongsoo Lee More articles by this author , Jong Won KimJong Won Kim More articles by this author , Jae Yong JeongJae Yong Jeong More articles by this author , Sung Ku KangSung Ku Kang More articles by this author , and Byung Ha ChungByung Ha Chung More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2017.02.461AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES To investigate the reference ranges for prostate volume (PV) and annual PV change rate, and to clarify the risk factors for the development of benign prostatic hyperplasia/lower urinary tract symptoms (BPH/LUTS) in healthy Korean men. METHODS A total of 11,222 healthy men who received transrectal ultrasonography at our hospital for a routine health check-up were included. Those with prior biopsies or surgery for prostate disease, or with BPH medication were excluded. BPH/LUTS was defined as International Prostate Symptom Score (IPSS)≥8 points and PV ≥30 mL. RESULTS The prostate-specific antigen (PSA) level, PSA density, PV, transitional zone volume (TV), and transitional zone index (TZI) increased significantly with age. The annual PV growth rate was 0.48 cm3/year. Body mass index, PSA, basal metabolism, fat mass, apolipoprotein A-1, high-density lipoprotein, aspartate aminotransferase, creatine, and urine pH were statistically associated with PV. PSA, fat mass, apolipoprotein A-1, creatine, and urine pH were significant predictive factors for both PV and TV. For men aged >40 years without prostate cancer history and treatment for BPH/LUTS, TZI (Hazzad ration (HR) =1.02, p = 0.001), total IPSS (HR = 1.04, p = 0.004) and alpha-fetoprotein (AFP) (HR = 0.86, p=0.040) were significant risk factors for the development of BPH/LUTS within 5 years. CONCLUSIONS This study showed that the TZI, total IPPS, and AFP were the major factors for the development of BPH/LUTS within 5 years in healthy Korean men. © 2017FiguresReferencesRelatedDetails Volume 197Issue 4SApril 2017Page: e160-e161 Advertisement Copyright & Permissions© 2017MetricsAuthor Information Kwang Suk Lee More articles by this author Kyo Chul Koo More articles by this author Do Kyung Kim More articles by this author Jongsoo Lee More articles by this author Jong Won Kim More articles by this author Jae Yong Jeong More articles by this author Sung Ku Kang More articles by this author Byung Ha Chung More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...