MP12-13 COITAL URINARY INCONTINENCE IN RATS

Abstract

You have accessJournal of UrologyUrodynamics/Incontinence/Female Urology: Basic Research II1 Apr 2015MP12-13 COITAL URINARY INCONTINENCE IN RATS José Luis Palacios, Margarita Juárez, Raúl Juárez, Alfonso Medel, and Yolanda Cruz José Luis PalaciosJosé Luis Palacios More articles by this author , Margarita JuárezMargarita Juárez More articles by this author , Raúl JuárezRaúl Juárez More articles by this author , Alfonso MedelAlfonso Medel More articles by this author , and Yolanda CruzYolanda Cruz More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2015.02.788AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Urinary incontinence during sexual intercourse, referred as coital urinary incontinence, has a devastating impact on female sexuality and quality of life. The aim of the present study was to determine the effect of the bilateral neurectomy of the DNC on micturition in female rats. METHODS Fifteen anesthetized Wistar virgin female rats underwent bilateral neurectomy of the DNC (DNCNX, n=9) or sham surgery (SH, n=6). The micturition was recorded in awake animals 3 and 10 days post-surgery, during 6 h of the dark phase cycle. Sexual behavior was tested at day 14 post-surgery. In order to get sexual receptivity, 48 h previous to the test the females were treated with 10 □g of benzoate estradiol and 44 h later 2 mg of progesterone was injected. During the coitus the urinary meatus of the female was zoom recorded in order to determine urine expulsion. Means among groups were compared with ANOVA, with P<0.05 indicating a significant difference. RESULTS Sham surgery did not significantly modified the values of the urinary parameters. However, in DNCNX females voiding frequency (p<0.05) and voiding duration significantly increased (p<0.05). Flow rate, voiding volume and voiding interval were not significantly affected. Seventy percent of the DNCNX animals expelled urine just after a penile intromission or male ejaculation. CONCLUSIONS These results suggest that genital deaferentation may be a causal factor of female coital urinary incontinence. Rats with bilateral transection of the DNC may be used as an animal model of coital incontinence. © 2015 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 193Issue 4SApril 2015Page: e132-e133 Advertisement Copyright & Permissions© 2015 by American Urological Association Education and Research, Inc.MetricsAuthor Information José Luis Palacios More articles by this author Margarita Juárez More articles by this author Raúl Juárez More articles by this author Alfonso Medel More articles by this author Yolanda Cruz More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...