MP12-06 SOCIOECONOMIC DETERMINANTS AS A PREDICTOR OF HORMONE AND SEMEN PARAMETERS

Abstract

You have accessJournal of UrologyCME1 Apr 2023MP12-06 SOCIOECONOMIC DETERMINANTS AS A PREDICTOR OF HORMONE AND SEMEN PARAMETERS Jordan Kassab and Larry Lipshultz Jordan KassabJordan Kassab More articles by this author and Larry LipshultzLarry Lipshultz More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000003227.06AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Social determinants of health, including economic resources, lifestyle choices, and access to adequate healthcare, have been shown to predict certain health outcomes. While past studies have indicated varying fertility outcomes as a result of social determinants of health, little research has been done to look into how biological markers are affected. Thus, the aim of this study is to investigate whether hormone and semen quality parameters are influenced by socioeconomic determinants. METHODS: Using the Distressed Community Index (DCI), disparate communities were identified by ZIP code within a ten-mile radius of our university hospital. The DCI compiles seven metrics regarding income and vulnerability to generate a percentile score with lower scores indicating better economic well-being. We identified zip codes that fall within the highest quintile of scores and zip codes that fall within the lowest quintile of scores in order to provide a stratified patient cohort. Using these zip codes, 179 urology patients were included in our retrospective chart analysis noting DNA fragmentation rates, testosterone, PSA, and total sperm count. T-tests for each parameter were calculated using SPSS. RESULTS: The statistical analysis revealed that semen parameters greatly differed between the low and high DCI score patient cohorts. The low DCI cohort had less than half of the DNA fragmentation rate of the high DCI cohort (12.64% vs. 30.50%, p=.0245). The low DCI group had significantly higher testosterone levels (632.5 ng/dL vs. 353.7 ng/dL, p=.00001). Additionally, PSA levels varied significantly between the low and high DCI groups (0.685 ng/mL vs. 3.28 ng/mL, respectively, p=.0125). Lastly, the total sperm count varied greatly between the two groups: the low DCI group had an average of 125 million and the high DCI group had an average of 68.3 million (p=.0316). CONCLUSIONS: Our study has demonstrated that men residing within wealthier and less vulnerable areas had documented more normal DNA fragmentation rates, testosterone and PSA levels, and total sperm counts. This relationship emphasizes the need to prioritize efforts towards supporting urologic care in disadvantaged communities. Our findings establish the basis for further population based studies to address the impact of socioeconomic status as a factor of urologic health outcomes. Source of Funding: None © 2023 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 209Issue Supplement 4April 2023Page: e135 Advertisement Copyright & Permissions© 2023 by American Urological Association Education and Research, Inc.MetricsAuthor Information Jordan Kassab More articles by this author Larry Lipshultz More articles by this author Expand All Advertisement PDF downloadLoading ...