MP12-06 MEDIUM-TERM OUTCOMES AFTER LAPAROSCOPIC ADRENALECTOMY FOR PRIMARY ALDOSTERONISM

Abstract

average during the 6 months post-operation. The change in eGFR before and after the operation was analyzed in each adrenal tumor. RESULTS: The mean change in eGFR before and after the operation was -14% (range, -55%-18%) in patients with PA, -9% (-48%23%) in patients with CS, -2% in patients with SCS, and -2% in patients with PCC. The eGFR decline in patients with PA and CS was significant (p < 0.0001 and p 1⁄4 0.0171, respectively), while there was no significant change in patients with SCS and PCC. After the operation, 39% (20/51) and 24% (5/21) of patients with PA and CS manifested renal dysfunction, respectively, while none of the patients with SCS and PCC manifested renal dysfunction. Preoperative renal function was not correlated with manifested renal dysfunction. Multivariate analysis identified older age and higher levels of plasma aldosterone concentration as independent predictors of renal dysfunction manifestation in patients with PA, while no clinical predictor was identified in patients with CS. CONCLUSIONS: This is the first report that has shown a decline in eGFR after adrenalectomy in patients with CS. Possible masked renal damage should be considered in patients with CS as well as PA.