MP12-05 THE IMPACT OF SOCIOECONOMIC STATUS ON THE SURVIVAL OF MEN WITH EARLY-ONSET PROSTATE CANCER

Abstract

You have accessJournal of UrologyCME1 Apr 2023MP12-05 THE IMPACT OF SOCIOECONOMIC STATUS ON THE SURVIVAL OF MEN WITH EARLY-ONSET PROSTATE CANCER Carlos Riveros, Victor Chalfant, Ahmed El-shafie, Allison H. Feibus, Mohammed Al-Toubat, Soroush Bazargani, SeyedBehzad Jazayeri, Mark Bandyk, and K.C. Balaji Carlos RiverosCarlos Riveros More articles by this author , Victor ChalfantVictor Chalfant More articles by this author , Ahmed El-shafieAhmed El-shafie More articles by this author , Allison H. FeibusAllison H. Feibus More articles by this author , Mohammed Al-ToubatMohammed Al-Toubat More articles by this author , Soroush BazarganiSoroush Bazargani More articles by this author , SeyedBehzad JazayeriSeyedBehzad Jazayeri More articles by this author , Mark BandykMark Bandyk More articles by this author , and K.C. BalajiK.C. Balaji More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000003227.05AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Prostate cancer (PC) is considered a disease of older men; about 10% of new diagnoses in the US occur in men ≤55 years old. Socioeconomic status (SES) has shown to influence survival in patients with PC; however, the impact of SES on men with early-onset PC remains undescribed. METHODS: Using the National Cancer Database, we identified men ≤55 years of age with PC between 2004-2018. Descriptive statistics were used to characterize differences among SES groups. Kaplan-Meier (KM) and Cox regression analyses were used to assess the effect of SES on overall survival (OS). To establish the impact of SES, the quartile assignments of median income and education level were combined to create a composite SES measure. Income and education level were determined by matching each patient’s zip code at the time of diagnosis with data derived from the 2016 American Community Survey on median household income and the percentage of people aged ≥25 years old who had not earned a high school diploma, respectively. The quartile assignments (Q1, Q2, Q3, Q4) of the income and education measures were added together to form 4 composite SES categories: 2-3=Low; 4-5=Mid-Low; 6-7=Mid-High; and 8=High. RESULTS: A total of 112,563 patients with early onset PC with a median follow-up of 79.0 months were included in the study cohort. Compared to high SES patients, low SES patients were more likely to be African American (42.4% vs. 8.6%; p<0.001), Hispanic (9.5% vs. 2.7%; p<0.001), and uninsured (5.2% vs. 1.1%; p<0.001); they were also more likely to live in a rural area (3.2% vs 0.1%; p<0.001) and have stage IV disease (5.5% vs. 3.1%; p<0.001). KM analysis showed that a decreasing SES was directly associated with lower rates of OS (log-rank test p<0.001). On multivariable analysis, SES was found to have a negative effect on OS (low SES vs. high SES; hazard ratio [HR] 1.54; 95% confidence interval [CI] 1.41-1.68; p<0.001) (Figure 1). CONCLUSIONS: In patients with early-onset PC, SES was associated with overall survival. SES should be considered when implementing programs to improve the management of patients with early-onset PC Source of Funding: none © 2023 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 209Issue Supplement 4April 2023Page: e134 Advertisement Copyright & Permissions© 2023 by American Urological Association Education and Research, Inc.MetricsAuthor Information Carlos Riveros More articles by this author Victor Chalfant More articles by this author Ahmed El-shafie More articles by this author Allison H. Feibus More articles by this author Mohammed Al-Toubat More articles by this author Soroush Bazargani More articles by this author SeyedBehzad Jazayeri More articles by this author Mark Bandyk More articles by this author K.C. Balaji More articles by this author Expand All Advertisement PDF downloadLoading ...