Abstract
INTRODUCTION AND OBJECTIVES:Our previous study has demonstrated calcium dependent chloride channel (CaCC) involving in the pathogenesis of cyclophosphamide (CYP)-induced overactive bladder (OAB). In this study, we investigated the effect of intravesical instillation of various CaCC blockers on voiding function evaluated by continuous infusion cystometry (CMG) in CYP-induced OAB rats.METHODS:CYP-induced OAB rat was provoked by four intraperitoneal injections (CYP-OAB group: 80 mg/kg; control: saline). Continuous infusion cystometry (CMG) was performed to record the basal pressure, maximum bladder voiding pressure (MBVP), intercontraction interval (ICI) and episodes of spontaneous contraction. At the end of baseline CMG, the infused physiological saline solution was replaced by one CaCC blocker solution for 30 minutes and then was replaced again by the same reagent at a higher concentration until the maximal effect was reached. The reagents used included niflumic acid (NFA), 4,4'-diisothiocyanato-stilbene-2...
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