Abstract
Epstein criteria which was developed using whole mount prostatectomy specimens. We estimated the detection rates of all CaP and clinically significant CaP. RESULTS: The median age and PSA were 64.9 years and 4.8 ng/mL respectively. Of the 63 men on AS that were eligible for analysis, the 87.3% (55/63) were classified as having CaP while 69.8% (44/63) were re-classified as having clinically significant. Fusion biopsy detected more clinically CaP compared with standard 12-core biopsy (60.3% vs 50.8%). Suspicion score on mpMRI was positively correlated with detection of clinically significant CaP (p1⁄40.0039; Figure 1). 100% of men with suspicion score of 5 on mpMRI had clinically significant CaP. CONCLUSIONS: Our results demonstrate that mpMRI may be useful in accurately identifying a significant proportion of men on AS who may harbor clinically significant CaP. Further evaluation in larger cohorts including randomized trials is needed to confirm these findings. As mpMRI data for CaP matures, we may be able to use these findings to better stratify patients for active surveillance and/or treatment.
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