MP10-14 PREDICTING INGUINAL AND PELVIC LYMPH NODE STATUS IN PENILE CANCER PATIENTS: A COMPARISON OF COMPUTED TOMOGRAPHY AND DISEASE BURDEN OF INGUINAL LYMPH NODES

Abstract

INTRODUCTION AND OBJECTIVES: We have previously reported an association between obesity and higher risk of invasive penile cancer in a hospital-based retrospective study. In order to validate the association between obesity and penile cancer at a population level, we conducted a matched case-control study linking the Iowa Department of Motor Vehicles Drivers’ License Database (DLD) with cancer surveillance data collected by the State Health Registry of Iowa (SHRI). METHODS: All men diagnosed with invasive penile squamous cell carcinoma from 1973 to 2010 were identified by the SHRI. Three hundred-thirty cancer cases and 990 cancer-free male controls, selected from the Iowa DLD, were matched within 5-year age and calendar year strata at a ratio of 3 controls to each case . Body mass index (BMI) was calculated using self-reported height and weight from the DLD. Conditional logistic regression was used to evaluate the association between BMI and the risk of developing invasive penile cancer. RESULTS: Penile cancer cases were significantly more likely to be overweight or obese as compared to controls. Compared to men with a normal weight (BMI < 25), the risk of invasive penile cancer increased with increasing obesity (Table). When BMI was treated as a continuous variable in the analysis, the risk of invasive penile cancer increased by an estimated 55% for every five-unit increase in BMI (Table). CONCLUSIONS: In this population-based matched case-control study, we found that increasing BMI was associated with a higher risk of developing invasive penile cancer. These results are consistent with our previous hospital-based study. Greater emphasis on education of obese men about this risk might encourage weight loss and persuade them to perform periodic genital self-examination.